Guidelines on prophylaxis to prevent infective endocarditis

British Dental Journal
M H ThornhillJ B Chambers

Abstract

Infective endocarditis is a devastating disease with high morbidity and mortality. The link to oral bacteria has been known for many decades and has caused ongoing concern for dentists, patients and cardiologists. Since 2008, the UK has been out of step with the rest of the world where antibiotic prophylaxis is recommended for high-risk patients undergoing invasive dental procedures. Recent evidence that identified an increase in endocarditis incidence prompted a guideline review by NICE and the European Society for Cardiology--which produces guidance for the whole of Europe. Despite reviewing the same evidence they reached completely opposing conclusions. The resulting conflict of opinions and guidance is confusing and poses difficulties for dentists, cardiologists and their patients. Recent changes in the law on consent, however, may provide a patient-centred and pragmatic solution to these problems. This Opinion piece examines the evidence and opposing guidance on antibiotic prophylaxis in the context of the recent changes in the law on consent and provides a framework for how patients at risk of endocarditis might be managed in practice.

References

Feb 19, 1999·BMJ : British Medical Journal·S H WoolfJ Grimshaw
Mar 5, 1999·BMJ : British Medical Journal·B Hurwitz
Sep 1, 2007·The Journal of Antimicrobial Chemotherapy·Paul Lee, David Shanson
Oct 3, 2009·The Journal of the American Dental Association·Peter B LockhartHowell C Sasser
May 1, 2015·The Journal of Antimicrobial Chemotherapy·Martin H ThornhillPeter B Lockhart
May 30, 2015·BMJ : British Medical Journal·Leroy C Edozien
Jun 13, 2015·British Dental Journal·M H ThornhillD Shanson
Sep 6, 2015·Lancet·Thomas J Cahill, Bernard D Prendergast
Sep 12, 2015·British Dental Journal·C ScullyJ A D Cameron
Oct 10, 2015·British Dental Journal·B G Main, S R L Adair

❮ Previous
Next ❯

Citations

Feb 25, 2017·Current Infectious Disease Reports·Martin H ThornhillBernard Prendergast
Aug 27, 2016·The British Journal of General Practice : the Journal of the Royal College of General Practitioners·Martin H ThornhillDavid Shanson
Apr 9, 2016·British Dental Journal·D McIntosh
Apr 9, 2016·British Dental Journal·P Alderson, M Baker
May 14, 2016·British Dental Journal·P Alderson, M Baker
Jul 9, 2016·British Dental Journal·M H ThornhillL M Baddour
Aug 16, 2016·British Dental Journal·M H ThornhillJ B Chambers
Dec 13, 2017·Singapore Dental Journal·Andrew Narendran Robinson, Paul Anantharajah Tambyah
Oct 16, 2019·Australian Dental Journal·S SukumarC J Adler
May 5, 2020·Journal of Evaluation in Clinical Practice·Joseph Vere, Barry Gibson
Aug 12, 2020·European Journal of Pediatrics·Daniel De WolfLuc Martens
Jul 14, 2019·British Dental Journal
Sep 15, 2018·British Dental Journal·Stephen Hancocks
Apr 11, 2020·Journal of Lasers in Medical Sciences·Amanda Vieira AiresRicardo Alves Mesquita

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved