Guillain-Barré syndrome complicating mobilization therapy in a case of B-cell chronic lymphocytic leukemia

Leukemia & Lymphoma
Giovanni D'ArenaNicola Di Renzo

Abstract

We report a case of Guillain-Barré Syndrome (GBS) which appeared after mobilization therapy in a patient with B-cell chronic lymphocytic leukemia (B-CLL). After obtaining a partial remission with four cycles of fludarabine at standard dose, the patient underwent to high-dose Cytoxan in order to mobilize CD34+ hematopoietic progenitor cells. During neutropenia the patient experienced fever of unknown origin (FUO) and subsequently developed GBS with normalization of his neurologic condition after 2 months. It is possible that a viral-induced activation of an antigen-specific T and B-cell clone caused a local inflammation and toxicity of Schwann cells with demyelination and axonal damage with a self-limited course.

References

Sep 1, 1994·Blood Reviews·S J WrightM J Keating
Apr 1, 1995·American Journal of Clinical Oncology·R MudadW P Peters
Apr 18, 2002·Bone Marrow Transplantation·V RodriguezR A Krance

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Citations

Apr 10, 2013·Journal of Medical Case Reports·Nischala AmmannagariEric Bravin
Jan 19, 2011·Haematologica·Kate HodgsonCarol Moreno
Jan 31, 2008·Leukemia & Lymphoma·Lin ZhangYi-Kong Keung
Jun 14, 2015·Journal of the Neurological Sciences·Joerg-Patrick Stübgen

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