Guillain-Barré syndrome variant with facial diplegia and paresthesias associated with IgM anti-GalNAc-GD1a antibodies

Internal Medicine
Ryuichiro Hayashi, Shigeki Yamaguchi

Abstract

We herein report the case of a 19-year-old woman with facial diplegia and paresthesias (FDP) preceded by flu-like symptoms. We diagnosed the patient with a regional variant of Guillain-Barré syndrome due to decreased tendon reflexes, albuminocytological dissociation in the cerebrospinal fluid and demyelinating features on nerve conduction studies. The patient also had IgM anti-GalNAc-GD1a antibodies, and treatment with glucocorticoids was effective for treating the facial diplegia, but not paresthesia. Therefore, facial palsy may have a different pathophysiology from paresthesia or other symptoms of FDP, which responds to glucocorticoid therapy.

References

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Aug 26, 2006·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·J DiedlerM Schwaninger
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Aug 29, 2009·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Nilgul YardimciSibel Benli

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Citations

Mar 28, 2019·SAGE Open Medical Case Reports·Kamal SharmaPaul Maertens

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