Guillain-Barré Syndrome, variants & forms fruste: Reclassification with new criteria

Clinical Neurology and Neurosurgery
Fu Liong HiewSanthi Puvanarajah

Abstract

This study aimed to evaluate the clinical and electrophysiological characteristics of various distinctive classical and localised Guillain-Barré syndrome (GBS) subtypes. Clinical characteristics and electrophysiological data of sixty-one consecutive patients admitted between 2012 and 2015 were systematically analysed and reclassified according to the new GBS clinical classification. Neurophysiology was evaluated with Hadden et al.'s vs recently proposed Rajabally et al.'s criteria. Functional severity and clinical outcome of various GBS subtypes were ascertained. All patients initially identified as GBS or related disorders can be sub-classified into having classical GBS (41, 67%), classic Miller-Fisher Syndrome (MFS) (6, 10%), Pharyngeal-cervical-brachial (PCB) (3, 5%), paraparetic GBS (4, 7%), bifacial weakness with paresthesia (3, 5%), acute ophthalmoparesis (AO) (1, 2%) and overlap syndrome (3, 5%): one (2%) with GBS/Bickerstaff brainstem encephalitis overlap and 2 (3%) with GBS/MFS overlap. Greater proportion of axonal classical GBS (67% vs 55%, p=0.372) seen with Rajabally et al.'s criteria and a predominantly axonal form of paraparetic variant (75%) independent of electrodiagnostic criteria were more representative of As...Continue Reading

Citations

Sep 22, 2019·Nature Reviews. Neurology·Sonja E LeonhardBart C Jacobs
Apr 28, 2020·PLoS Neglected Tropical Diseases·Sonja E LeonhardMaria de Fatima P Militão de Albuquerque
Jun 5, 2020·Acta Neurologica Scandinavica·Pingping NingYanming Xu
Jun 9, 2020·Journal of the Peripheral Nervous System : JPNS·Cheng-Yin TanNortina Shahrizaila
Apr 25, 2019·BMJ Case Reports·Sajid Hameed, Sara Khan
Apr 10, 2021·Journal of Clinical Neurology·Cheng Yin TanNortina Shahrizaila
Jun 9, 2021·Neurological Research·Yan LiChuansheng Zhao
May 6, 2021·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Mohammad AladawiEzequiel Piccione
Jul 26, 2021·Clinical Neurology and Neurosurgery·Miraç YıldırımTanıl Kendirli
Apr 2, 2020·Case Reports in Neurology·Prangsai Wattanasit, Pornchai Sathirapanya

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