Guinea pig serum L-asparaginase: purification, and immunological relationship to liver L-asparaginase and serum L-asparaginases in other mammals

Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology
N ZhangI Beacham

Abstract

L-asparaginase, an enzyme used in the treatment of acute lymphocytic leukemia, is found in the serum of only a few mammalian groups, including the guinea pig and its close relatives in the superfamily Cavioidea. This report describes the purification and characterization of L-asparaginase from guinea pig serum. Antiserum against the purified enzyme cross-reacted with sera from other Cavioidean species but not with mouse serum. Relatively weak cross-reaction with unpurified L-asparaginase in guinea pig liver indicates a significant degree of evolutionary divergence.

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Citations

Nov 9, 2015·Applied Biochemistry and Biotechnology·Tahira BatoolMashitah M Yusoff
May 13, 2009·Journal of Biotechnology·Mohammad Reza Tabandeh, Mahmood Aminlari

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