Guinea pigs develop cutaneous basophilia after repeated infestations by nymphs of the tick Amblyomma triste

Annals of the New York Academy of Sciences
F M S Otávio, G H Bechara

Abstract

This study investigated the development of resistance in guinea pigs to nymphs of Amblyomma triste ticks after repeated infestations. Guinea pigs were infested thrice, at 30-day intervals, with 30 nymphs of A. triste per animal per infestation. Acquisition of resistance was evaluated by determining: nymph yielding rate, engorgement period, and weight. Skin biopsies of tick bite sites were collected at 24, 48, and 96 h after tick attachment for inflammatory cell counts. Engorged nymphs weighed 5.53 mg +/- 1.9 in re-infested hosts (56.6% less than in primary infestation) and took 6.9 days +/- 2.16 to feed in the third infestation (14.5% more than in the first infestation). Guinea pigs yielded 78%+/- 7.2 of nymphs in the re-infestation (11.6% less than in the primary infestation). In addition, a marked increase in basophil influx was observed from the first infestation onward; 69% of infiltrated cells were basophils in re-infested hosts 24 h after tick attachment. No basophils were seen at this time in primary infested animals. That number increased to 84.7% 48 h post attachment in re-infested hosts (73.2% more than in the primary infested ones) and decreased markedly 96 h post attachment in both groups (2.6% and 1% of basophils i...Continue Reading

References

Jan 1, 1996·Annual Review of Entomology·S K Wikel

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Citations

Nov 1, 2011·Current Opinion in Immunology·David Voehringer
Jul 21, 2015·Journal of Proteomics·Jan KotálJindřich Chmelař
Oct 31, 2020·Parasite Immunology·Soichiro YoshikawaHajime Karasuyama

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