Gum arabic reduces inflammation, oxidative, and nitrosative stress in the gastrointestinal tract of mice with chronic kidney disease.

Naunyn-Schmiedeberg's Archives of Pharmacology
Badreldin H AliAbderrahim Nemmar

Abstract

The aim of this study was to investigate some biochemical indices of inflammation and oxidative and nitrosative stresses in the gastrointestinal tract of mice with experimental chronic kidney disease (CKD) and treated with gum arabic (GA). Male CD1 mice (n = 28) were randomly distributed into four groups and treated for four consecutive weeks: group 1: Control: received the same diet without treatment until the end of the study; group 2: Adenine: switched to a powder diet containing adenine (0.2% w/w in feed); group 3: Gum acacia (GA): given normal feed and GA in drinking water at a concentration of 15% w/v; and group 4: Adenine + GA: given adenine in the feed as in the second group plus GA in the drinking water at concentration of 15% w/v. CKD was induced to mice by adenine feeding and concomitantly treated with the prebiotic dietary fiber gum acacia, GA (15% in drinking water). Duodenal mucosa from CKD mice had significantly higher concentrations of TNF-alfa, IL- 6, and TGF-beta-1 and lipid peroxidation. Moreover, low concentrations of IL-10, some antioxidants (catalase, glutathione reductase, total antioxidant capacity, and superoxide dismutase), and nuclear factor erythroid 2-related factor 2 were found in the duodenum. The...Continue Reading

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Citations

Nov 18, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Arun Prasath LakshmananAnnalisa Terranegra
Jan 30, 2021·Oxidative Medicine and Cellular Longevity·Abderrahim NemmarBadreldin H Ali
Jul 27, 2021·ACS Omega·Muhamad Hanif RawiShahrul Razid Sarbini

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Methods Mentioned

BETA
ELISA
light microscopy
MDA

Software Mentioned

GraphPad Prism

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