Gum tragacanth/poly(l-lactic acid) nanofibrous scaffolds for application in regeneration of peripheral nerve damage

Carbohydrate Polymers
Marziyeh Ranjbar-MohammadiS Ramakrishna

Abstract

Nanofibrous nerve guides have gained huge interest in supporting the peripheral nerve regeneration due to their abilities to simulate the topography, mechanical, biological and extracellular matrix morphology of native tissue. Gum tragacanth (GT) is a biocompatible mixture of polysaccharides that has been used in biomedical applications. During this study, we fabricated aligned and random nanofibers from poly(l-lactic acid) and gum tragacanth (PLLA/GT) in various ratios (100:0, 75:25, and 50:50) by electrospinning. Scanning electron microscope demonstrated smooth and uniform nanofibers with diameters in the range of 733±65nm and 226±73nm for align PLLA and random PLLA/GT 50:50 nanofibers, respectively. FTIR analysis, contact angle, in vitro biodegradation and tensile measurements were carried out to evaluate the chemical and mechanical properties of the different scaffolds. PLLA/GT 75:25 exhibited the most balanced properties compared to other scaffolds and was used for in vitro culture of nerve cells (PC12) to assess the potential of using these scaffolds as a substrate for nerve regeneration. The cells were found to attach and proliferate on aligned PLLA/GT 75:25 scaffolds, expressing bi-polar neurite extensions and the orien...Continue Reading

References

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Citations

Aug 16, 2016·Carbohydrate Polymers·María Luisa López-CastejónInmaculada Martínez
Sep 11, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Marziyeh Ranjbar-MohammadiF Moayer
Oct 30, 2016·International Journal of Biological Macromolecules·Zahra ZarekhaliliPeiman Brouki Milan
Jul 6, 2017·Pharmaceuticals·Angela FaccendiniFranca Ferrari
Jun 14, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Senthilguru KulanthaivelIndranil Banerjee
Apr 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mohammad Ehsan Taghavizadeh YazdiSaeid Kargozar
Jun 22, 2019·International Journal of Biological Macromolecules·Suhail AhmadSaiqa Ikram

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