Guselkumab in the treatment of concomitant hidradenitis suppurativa, psoriasis, and Crohn's disease.

The Journal of Dermatological Treatment
Hannah S BermanJennifer L Hsiao

Abstract

Hidradenitis suppurativa (HS) is a debilitating skin condition whose pathogenesis is poorly understood, although interleukin (IL)-23 may play a role. IL-23 is also implicated in the pathogenesis of Crohn's disease (CD) and psoriasis, both of which can occur in patients with HS. We present the case of a 28-year-old woman with HS, psoriasis, and CD, who was successfully treated with guselkumab after failing multiple other biologic agents. Guselkumab represents a promising therapeutic option for recalcitrant HS patients with inflammatory comorbidities in which IL-23 plays a role.

References

Mar 27, 2009·The Journal of Investigative Dermatology·Antonella Di CesareFrank O Nestle
Mar 23, 2010·Cell·Dan R Littman, Alexander Y Rudensky
Jun 7, 2011·Journal of the American Academy of Dermatology·Christoph SchlapbachRobert E Hunger
Dec 19, 2012·Annals of Internal Medicine·Alexa B KimballGregor B E Jemec
Jun 26, 2014·International Journal of Dermatology·Genevieve KellyBrian Kirby
Oct 17, 2015·Journal of the American Academy of Dermatology·John J KohorstMark D P Davis
Mar 12, 2016·Journal of the American Academy of Dermatology·Coline FaivreUNKNOWN French Society of Dermatology and Club Rheumatisms and Inflammation
Oct 30, 2016·Journal of the American Academy of Dermatology·Inge E DeckersErrol P Prens
Feb 28, 2018·Expert Opinion on Biological Therapy·Matteo MegnaNicola Balato
Oct 12, 2018·Dermatology and Therapy·Alexandra B KimballArijit Ganguli
Nov 28, 2018·Journal of the European Academy of Dermatology and Venereology : JEADV·M Kovacs, M Podda
Dec 19, 2018·Journal of the American Academy of Dermatology·Rachel G CasseresDavid Rosmarin
Mar 14, 2019·Inflammatory Bowel Diseases·Laurie B Grossberg
May 11, 2019·Current Opinion in Pharmacology·Łukasz MatusiakJacek C Szepietowski

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Citations

Feb 23, 2020·Expert Opinion on Biological Therapy·Monica Rosales SantillanAlexa B Kimball
Apr 23, 2020·Dermatologic Therapy·Trinidad Montero-VilchezAlejandro Molina-Leyva
Jul 15, 2020·Digestive Diseases and Sciences·Neil NadparaFrank Friedenberg
Oct 20, 2020·The Journal of Dermatological Treatment·Claudio ConfortiNicoleta Neagu
Dec 17, 2020·Dermatology : International Journal for Clinical and Investigative Dermatology·Andreas PinterAndrea Chiricozzi

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