Gustatory sensation of (L)- and (D)-amino acids in humans

Amino Acids
Misako KawaiYuzo Ninomiya

Abstract

Amino acids are known to elicit complex taste, but most human psychophysical studies on the taste of amino acids have focused on a single basic taste, such as umami (savory) taste, sweetness, or bitterness. In this study, we addressed the potential relationship between the structure and the taste properties of amino acids by measuring the human gustatory intensity and quality in response to aqueous solutions of proteogenic amino acids in comparison to D-enantiomers. Trained subjects tasted aqueous solution of each amino acid and evaluated the intensities of total taste and each basic taste using a category-ratio scale. Each basic taste of amino acids showed the dependency on its hydrophobicity, size, charge, functional groups on the side chain, and chirality of the alpha carbon. In addition, the overall taste of amino acid was found to be the combination of basic tastes according to the partial structure. For example, hydrophilic non-charged middle-sized amino acids elicited sweetness, and L-enantiomeric hydrophilic middle-sized structure was necessary for umami taste. For example, L-serine had mainly sweet and minor umami taste, and D-serine was sweet. We further applied Stevens' psychophysical function to relate the total-tas...Continue Reading

References

Jan 1, 1989·Comparative Biochemistry and Physiology. A, Comparative Physiology·Y Ninomiya, M Funakoshi
Nov 1, 1985·Physiology & Behavior·J H Kroeze, L M Bartoshuk
Dec 15, 1965·Experientia·J SolmsR H Egli
Jul 2, 1966·Nature·E W Deutsch, C Hansch
Jan 1, 1980·Neurobiology of Aging·S S Schiffman, T B Clark
Jul 1, 1981·Physiology & Behavior·S S SchiffmanJ Gagnon
Mar 25, 1999·Cell·B MalnicL B Buck
Apr 13, 2000·Cell·J ChandrashekarN J Ryba
Dec 2, 2000·Nature Neuroscience·R C AranedaS Firestein
Aug 18, 2001·Cell·G NelsonC S Zuker
Mar 15, 2002·Nature·Greg NelsonCharles S Zuker
Mar 28, 2002·Proceedings of the National Academy of Sciences of the United States of America·Xiaodong LiElliot Adler
Oct 16, 2002·Chemical Senses·Misako KawaiYoichi Ueda
Nov 26, 2003·Cell·Grace Q ZhaoCharles S Zuker
Aug 25, 2006·Nature·Angela L HuangCharles S Zuker
Aug 29, 2007·Proceedings of the National Academy of Sciences of the United States of America·Hyeung-Jin JangJosephine M Egan
Dec 24, 2008·Proceedings of the National Academy of Sciences of the United States of America·Feng ZhangXiaodong Li
Jan 29, 2010·Nature·Jayaram ChandrashekarCharles S Zuker

❮ Previous
Next ❯

Citations

Aug 7, 2012·Amino Acids·Ana San Gabriel, Hisayuki Uneyama
Dec 12, 2012·Journal of Agricultural and Food Chemistry·Susann KohlWolfgang Meyerhof
Nov 12, 2013·The Journal of Biological Chemistry·Yasuka TodaTakumi Misaka
Jan 25, 2007·Journal of Bioinformatics and Computational Biology·Jian GuoHoward Leung
Jul 9, 2013·Bioscience, Biotechnology, and Biochemistry·Seulki LeeMichihiro Fukushima
May 2, 2015·Molecular Nutrition & Food Research·Jie YinGuoyao Wu
Jul 24, 2014·Food Chemistry·Xiaobei LiYan Yang
Oct 31, 2015·Aging Clinical and Experimental Research·Mélanie PougetIsabelle Papet
Jul 12, 2016·International Journal of Molecular Sciences·Tsutomu SasakiTadahiro Kitamura
Aug 5, 2017·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Kimberly R Smith, Alan C Spector
Jun 12, 2018·Journal of the Science of Food and Agriculture·Jose L PerezBhimanagouda S Patil
Jul 22, 2020·Animal Science Journal = Nihon Chikusan Gakkaihō·Yusuke KomiyaKeizo Arihara
Aug 8, 2020·Journal of the Science of Food and Agriculture·Domenico CautelaNunzia DʼOnofrio
Jul 13, 2018·BMC Plant Biology·Geeta KumariJames P Tam
May 6, 2020·Scientific Reports·Alexander O Kasumyan, Grigoryi E Mouromtsev
Feb 5, 2019·Frontiers in Molecular Biosciences·Waldo Acevedo, Piero A Temussi
Sep 25, 2019·Nutrients·Jacco J A J BastingsSander S Rensen
Aug 8, 2020·Animal Science Journal = Nihon Chikusan Gakkaihō·Mitsuru KamiyaMikito Higuchi
Dec 26, 2018·Food Chemistry·Minna Rotola-PukkilaAnu Hopia
Jan 16, 2021·Journal of Fish Biology·Aleksandra D LevinaAlexander O Kasumyan
Dec 18, 2019·Microorganisms·Jyumpei Kobayashi
Nov 20, 2020·Scientific Reports·Charlotte Vinther SchmidtOle G Mouritsen
Aug 8, 2021·Animals : an Open Access Journal From MDPI·Liliana Di Stasio, Alberto Brugiapaglia
Nov 26, 2020·Food Research International·Samara Dos Santos Harada-PadermoThais Maria Ferreira de Souza Vieira

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
Xiaodong LiElliot Adler
British Dental Journal
R W Linden
© 2021 Meta ULC. All rights reserved