PMID: 9539456Apr 16, 1998Paper

Gustducin and its role in taste

Journal of Dental Research
A I Spielman

Abstract

The mechanisms responsible for taste signal transductions are very complex. A key molecule, alpha-gustducin, a primarily taste-specific G protein alpha-subunit, was discovered in 1992 and was later found to be involved in both bitter and sweet taste transduction. A proposed mechanism for alpha-gustducin involves coupling specific cell-surface receptors with a cyclic nucleotide phosphodiesterase which would open a cyclic nucleotide-suppressible cation channel leading to influx of calcium, and ultimately leading to release of neurotransmitter. Although "knock-out" animals deficient in the alpha-gustducin gene clearly demonstrate that gustducin is an essential molecule for tasting certain bitter and sweet compounds, the precise role of alpha-gustducin in bitter and sweet taste is presently unclear. Indeed, there are several other signaling mechanisms in sweet and bitter taste, apparently unrelated to alpha-gustducin, that increase cyclic AMP or inositol 1,4,5 trisphosphate. Thus, proposed models for alpha-gustducin and those found by other laboratories may be parallel and interdependent.

References

Jan 1, 1990·Annual Review of Pharmacology and Toxicology·L Birnbaumer
Oct 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·P M HwangS H Snyder
Sep 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·S C KinnamonK G Beam
Jul 15, 1995·The Biochemical Journal·M A HoonN J Ryba
Dec 1, 1994·Physiology & Behavior·S K McLaughlinR F Margolskee
Mar 1, 1994·Brain Research. Molecular Brain Research·S TakamiM L Getchell
Feb 1, 1994·The Biochemical Journal·M NaimG Schultz
Mar 1, 1993·The Journal of Allergy and Clinical Immunology·B J CowartL D Lowry
Mar 1, 1996·The American Journal of Physiology·A I SpielmanJ G Brand
Jun 27, 1996·Nature·G T WongR F Margolskee
Jun 25, 1996·Proceedings of the National Academy of Sciences of the United States of America·D HöferD Drenckhahn
Jul 1, 1996·Physiological Reviews·B Lindemann
Aug 1, 1996·Current Opinion in Neurobiology·S C Kinnamon, R F Margolskee
Oct 1, 1996·Current Biology : CB·B Lindemann
Jan 1, 1997·Annual Review of Pharmacology and Toxicology·D E Clapham, E J Neer
Sep 5, 1997·The Journal of Biological Chemistry·T MisakaK Abe

❮ Previous
Next ❯

Citations

Sep 12, 2000·Current Opinion in Neurobiology·T A GilbertsonR F Margolskee
Apr 1, 1999·Annual Review of Physiology·M S Herness, T A Gilbertson
Dec 19, 2013·Critical Reviews in Food Science and Nutrition·Adam I CygankiewiczWanda M Krajewska
Nov 3, 2016·Comparative Biochemistry and Physiology. Part D, Genomics & Proteomics·Sen GaoZhanjiang Liu
Nov 7, 2001·The Journal of Biological Chemistry·Robert F Margolskee
Jul 11, 2001·Nutrition Reviews·A Drewnowski
Mar 14, 2001·American Journal of Physiology. Cell Physiology·W YanA I Spielman
Oct 9, 2020·Pflügers Archiv : European journal of physiology·Elena von MolitorTiziana Cesetti
Oct 31, 2020·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Elizabeth A SellNoam A Cohen
Jul 10, 2021·Frontiers in Human Neuroscience·Elena von MolitorTiziana Cesetti

❮ Previous
Next ❯

Related Concepts

Related Feeds

Calcium & Bioenergetics

Bioenergetic processes, including cellular respiration and photosynthesis, concern the transformation of energy by cells. Here is the latest research on the role of calcium in bioenergetics.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
D MingR F Margolskee
Current Opinion in Neurobiology
S C Kinnamon, R F Margolskee
Neuron
J W Lewcock, R R Reed
© 2022 Meta ULC. All rights reserved