PMID: 8944702Nov 1, 1996Paper

Gut adaptation and the insulin-like growth factor system: regulation by glutamine and IGF-I administration

The American Journal of Physiology
Thomas R ZieglerR J Smith

Abstract

Intestinal adaptation after extensive small bowel resection in rats is augmented by the provision of diets supplemented with the amino acid glutamine (Gln) or by administration of insulin-like growth factor-I (IGF-I). The goal of this study was to investigate potential synergistic effects of Gln and IGF-I on postresection ileal hyperplasia. Rats underwent 80% small bowel resection (SBR) and then were fed low-Gln or L-Gln-enriched diets and subcutaneously given recombinant human IGF-I or vehicle for 7 days. Gln and IGF-I each significantly enhanced adaptive ileal hyperplasia (DNA content) compared with rats receiving vehicle and low-Gln diet. Ileal DNA content was highest when IGF-I was administered together with Gln supplementation. Combined IGF-I plus Gln synergistically increased ileal weight and protein content. This was associated with higher plasma concentrations of IGF-I and Gln than observed when IGF-I or Gln was given individually. Ileal IGF-I mRNA expression rose nearly twofold during gut adaptation after SBR; this response was augmented with IGF-I administration but was unaltered by Gln feeding. In contrast, dietary Gln, but not IGF-I therapy, prevented a decrease in hepatic IGF-I mRNA induced by SBR. We conclude that...Continue Reading

Citations

Feb 8, 2002·World Journal of Gastroenterology : WJG·Cameron F E PlatellJohn C Hall
May 24, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Elizabeth M DahlyDenise M Ney
Nov 29, 2007·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Y Avery ChingTom Jaksic
Feb 21, 2009·World Journal of Gastroenterology : WJG·Laurie A DrozdowskiAlan B R Thomson
Oct 22, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Melanie B GillinghamDenise M Ney
Oct 23, 2001·American Journal of Physiology. Gastrointestinal and Liver Physiology·M B GillinghamD M Ney
Aug 19, 2005·JPEN. Journal of Parenteral and Enteral Nutrition·Mary E EvansThomas R Ziegler
May 15, 2004·American Journal of Physiology. Gastrointestinal and Liver Physiology·Andrew W KnottBrad W Warner
Aug 29, 2006·World Journal of Gastroenterology : WJG·Laurie Drozdowski, Alan B R Thomson
Oct 22, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Concepcion Fernandez-EstivarizThomas R Ziegler
Feb 9, 2000·American Journal of Physiology. Endocrinology and Metabolism·K R KritschD M Ney
Dec 14, 2011·Pediatric Surgery International·Mitsugu OwariMasahiro Fukuzawa
Apr 1, 2006·American Journal of Physiology. Gastrointestinal and Liver Physiology·Carmen Z MichayliraP Kay Lund
Dec 4, 2003·Best Practice & Research. Clinical Gastroenterology·A ThiesenG Wild

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