Gut-associated lymphoid tissue, gut microbes and susceptibility to experimental autoimmune encephalomyelitis

Beneficial Microbes
S StanisavljevićDjordje Miljkovic

Abstract

Gut microbiota and gut-associated lymphoid tissue have been increasingly appreciated as important players in pathogenesis of various autoimmune diseases, including multiple sclerosis. Experimental autoimmune encephalomyelitis (EAE) is an animal model of multiple sclerosis that can be induced with an injection of spinal cord homogenate emulsified in complete Freund's adjuvant in Dark Agouti (DA) rats, but not in Albino Oxford (AO) rats. In this study, mesenteric lymph nodes (MLN), Peyer's patches (PP) and gut microbiota were analysed in these two rat strains. There was higher proportion of CD4(+) T cells and regulatory T cells in non-immunised DA rats in comparison to AO rats. Also, DA rat MLN and PP cells were higher producers of pro-inflammatory cytokines interferon-γ and interleukin-17. Finally, microbial analyses showed that uncultivated species of Turicibacter and Atopostipes genus were exclusively present in AO rats, in faeces and intestinal tissue, respectively. Thus, it is clear that in comparison of an EAE-susceptible with an EAE-resistant strain of rats, various discrepancies at the level of gut associated lymphoid tissue, as well as at the level of gut microbiota can be observed. Future studies should determine if the...Continue Reading

References

Jun 5, 1983·Journal of Molecular Biology·D Hanahan
Jan 1, 1996·Current Opinion in Hematology·K Marusina, J J Monaco
Aug 1, 2002·International Journal of Systematic and Evolutionary Microbiology·Philipp P BosshardMartin Altwegg
Jan 29, 2003·Current Opinion in Pharmacology·Neil Upton, Sharon Stratton
Mar 5, 2004·Journal of Agricultural and Food Chemistry·Bart A SmitGerrit Smit
Mar 20, 2004·Clinical and Experimental Immunology·S Stosic-GrujicicM Mostarica-Stojkovic
Aug 11, 2006·Current Opinion in Ophthalmology·Stella K Kim
Nov 1, 2008·The American Journal of Pathology·Hiroaki YokoteTakashi Yamamura
Oct 21, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Javier Ochoa-RepárazLloyd H Kasper
Dec 17, 2009·Applied and Environmental Microbiology·Laura L PresleyJames Borneman
Apr 12, 2011·FEBS Letters·Franziska Petermann, Thomas Korn
Jul 19, 2011·Nature·Enric EspluguesRichard A Flavell
Sep 17, 2011·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Rebecca A Sosa, Thomas G Forsthuber
Oct 28, 2011·Nature·Kerstin BererGurumoorthy Krishnamoorthy
Sep 14, 2012·Nature·Craig L MaynardCasey T Weaver
Oct 12, 2012·Current Hypertension Reports·Jonathan A StiberPaul B Rosenberg
Jul 16, 2013·Applied and Environmental Microbiology·Jovanka LukicJelena Begovic
Sep 26, 2013·Acta Microbiologica Et Immunologica Hungarica·Vesna Kovačević-JovanovićMirjana Dimitrijević
Dec 10, 2013·The Journal of Clinical Investigation·Danielle CalifanoDorina Avram
Nov 21, 2014·Science Translational Medicine·Viorica BranisteSven Pettersson
Apr 23, 2015·Biomedical Journal·Florian C Kurschus
Jun 2, 2015·Nature Neuroscience·Daniel ErnyMarco Prinz
Jul 16, 2015·Nutrition Reviews·John BienenstockPaul Forsythe
Jul 18, 2015·Molecular Nutrition & Food Research·Yadong ZhongFrida Fåk
Aug 8, 2015·Nature Reviews. Immunology·Calliope A DendrouManuel A Friese

❮ Previous
Next ❯

Citations

May 26, 2017·European Journal of Immunology·Kumaraswamy Naidu ChitralaMitzi Nagarkatti
Jan 19, 2018·Behavioral Sciences·Giselle Pentón-Rol, Majel Cervantes-Llanos
May 29, 2018·Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association·Zeyu WangDongqiang Zhao
Sep 19, 2017·Probiotics and Antimicrobial Proteins·Banafsheh Douzandeh-Mobarrez, Ashraf Kariminik
Jan 24, 2018·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·M Kh KozhievaA N Boyko
May 18, 2018·Frontiers in Immunology·Suzana StanisavljevićĐorđe Miljković
Aug 25, 2020·Mediators of Inflammation·Kanglan LiBin Zhao
Dec 27, 2016·Frontiers in Microbiology·Suzana StanisavljevićNatasa Golić
Apr 30, 2021·Frontiers in Immunology·Đorđe MiljkovićMirjana Dimitrijević

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.