Gut bacterial translocation during total parenteral nutrition in experimental rats and its countermeasure

American Journal of Surgery
H NakasakiK Fujii

Abstract

The use of total parenteral nutrition (TPN) is commonly associated with mucosal lining of the intestinal tract, causing degenerative changes within the gut-associated lymphoid tissue (GALT). These phenomena are probably caused by the translocation of indigenous intestinal bacteria into other organs and tissues where they induce infections. Using TPN model rats, this paper looks at the result of the investigation of the action of PSK (proteoglycan), a biological response modifier, which appears to suppress bacterial translocation and maintain local immunity activity. Culture of mesenteric lymph nodes obtained post-TPN demonstrate a bacterial rate as high as 60%. Immunohistochemical examination indicates a reduction in the number of plasma cells and a decrease in S-IgA production and secretion. A similar reduction in S-IgA within bile and portal venous blood was also confirmed. Continuous oral administration of PSK in a daily dose of 1,000 mg/kg had a protective effect against the degeneration of GALT. A staining in immunocytes of Peyer's patches using immunohistochemical study was performed after administration of PSK and revealed constant levels of MHC-I, MHC-II, T helper cells, and interleukin-2 producing cells, supporting the...Continue Reading

References

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Citations

Dec 13, 2005·European Journal of Clinical Nutrition·M A T MuftuogluA Saglam
Jun 4, 2004·BMJ : British Medical Journal·Paul E Marik, Gary P Zaloga
Jul 1, 1999·Clinics in Chest Medicine·A LioliosE Benjamin
May 18, 1999·The Journal of Surgical Research·G ZallenC C Silliman
Feb 20, 2007·JPEN. Journal of Parenteral and Enteral Nutrition·Yoshinori FujimuraRobert L Owen
Oct 2, 2015·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Farokh R DemehriDaniel H Teitelbaum
Jul 9, 2004·World Journal of Gastroenterology : WJG·Xiao-Dong BaiQing-Ying Tong
Dec 6, 2018·Nutrition Reviews·Maude Le GallJohanne Le Beyec
Aug 10, 2019·Journal of the American College of Nutrition·Sabrina M SaeedJose M Pimiento
Mar 31, 2004·World Journal of Gastroenterology : WJG·Lian-An Ding, Jie-Shou Li
Jul 16, 2003·Intensive Care Medicine·Paul E Marik, Michael Pinsky
Feb 4, 2003·Alimentary Pharmacology & Therapeutics·J Goh, C A O'Morain
Nov 30, 2020·Microbial Pathogenesis·Yan-Hua Wang

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