Gut colonization with vancomycin-resistant Enterococcus and risk for subsequent enteric infection

Gut Pathogens
Jordan E AxelradDaniel E Freedberg

Abstract

Gut colonization with vancomycin-resistant Enterococcus (VRE) is associated with poor outcomes. This study evaluated the impact of VRE colonization on subsequent acquisition of enteric pathogens. We performed a retrospective cohort study of adults admitted to an ICU from 2012 to 2017 who were screened for VRE colonization and subsequently underwent stool testing with a gastrointestinal pathogen PCR panel (GI PCR) with or without PCR testing for Clostridium difficile. Our primary outcome was the presence of any enteric pathogen. Cox proportional hazards modeling was used to adjust for factors associated with enteric infection. Of 761 patients who underwent VRE screening and subsequent GI PCR, 131 (17%) were colonized with VRE. Patients with VRE colonization were less likely to test positive on GI PCR compared to patients without VRE (9.2% vs 18%, p = 0.01); specifically for E. coli species (p = 0.03) and viral (p = 0.04) enteric infections. In 716 patients who underwent C. difficile testing, there was a trend towards more C. difficile infections in patients colonized with VRE (15% vs 10%, p = 0.11). On multivariable analysis, patients with VRE had a decreased risk of a positive GI PCR (aHR 0.47, 95% CI 0.25-0.88, p = 0.02) but n...Continue Reading

References

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Citations

Jan 18, 2019·Journal of Clinical Microbiology·Jordan E AxelradDaniel A Green
Apr 16, 2021·Nature Communications·Matilda BerkellUNKNOWN ANTICIPATE study group

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Methods Mentioned

BETA
PCR

Software Mentioned

SPSS

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