Gut-microbe derived TMAO and its association with more progressed forms of AF: Results from the AF-RISK study.

IJC Heart & Vasculature
B O NguyenM Rienstra

Abstract

The importance of gut microbiome in cardiovascular disease has been increasingly recognized. Trimethylamine N-oxide (TMAO) is a gut microbe-derived metabolite that is associated with cardiovascular disease, including atrial fibrillation (AF). The role of TMAO in clinical AF progression however remains unknown. In this study we measured TMAO and its precursor (betaine, choline, and L- carnitine) levels in 78 patients using plasma samples from patients that participated in the AF-RISK study. 56 patients suffered from paroxysmal AF and 22 had a short history of persistent AF. TMAO levels were significantly higher in patients with persistent AF, as compared to those with paroxysmal AF (median [IQR] 5.65 [4.7-9.6] m/z versus 4.31 [3.2-6.2] m/z, p < 0.05), while precursor levels did not differ. In univariate analysis, we observed that for every unit increase in TMAO, the odds for having persistent AF increased with 0.44 [0.14-0.73], p < 0.01. Conclusion: These results suggest that higher levels of TMAO are associated with more progressed forms of AF. We therefore hypothesize that increased TMAO levels may reflect disease progression in humans. Larger studies are required to validate these preliminary findings.Trial Registration numbe...Continue Reading

References

Jun 30, 2018·International Journal of Cardiology·Gard F T SvingenOttar Nygård
Dec 26, 2018·Circulation Research·Eelke BrandsmaDebby P Y Koonen
Apr 27, 2019·Journal of the American College of Cardiology·W H Wilson TangStanley L Hazen
Dec 23, 2019·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Ruben R De WithIsabelle C Van Gelder
Mar 28, 2020·Scientific Reports·Martin KummenJohannes R Hov
Aug 9, 2020·Circulation Research·Marco WitkowskiStanley L Hazen

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