Gut Microbial-Derived Metabolomics of Asthma.

Metabolites
Kathleen A Lee-SarwarScott T Weiss

Abstract

In this review, we discuss gut microbial-derived metabolites involved with the origins and pathophysiology of asthma, a chronic respiratory disease that is influenced by the microbiome. Although both gut and airway microbiomes may be important in asthma development, we focus here on the gut microbiome and metabolomic pathways involved in immune system ontogeny. Metabolite classes with existing evidence that microbial-derived products influence asthma risk include short chain fatty acids, polyunsaturated fatty acids and bile acids. While tryptophan metabolites and sphingolipids have known associations with asthma, additional research is needed to clarify the extent to which the microbiome contributes to the effects of these metabolites on asthma. These metabolite classes can influence immune function in one of two ways: (i) promoting growth or maturity of certain immune cell populations or (ii) influencing antigenic load by enhancing the number or species of specific bacteria. A more comprehensive understanding of how gut microbes and metabolites interact to modify asthma risk and morbidity will pave the way for targeted diagnostics and treatments.

References

Aug 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·R YoshidaO Hayaishi
May 4, 1999·The Journal of Experimental Medicine·D H MunnA L Mellor
Jul 1, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·K YamazakiG J Gleich
Mar 18, 2000·Advances in Experimental Medicine and Biology·C R MacKenzieW Däubener
May 10, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·A J AmmitR A Panettieri
Mar 15, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Leah D WhighamMark E Cook
Dec 21, 2002·Journal of Applied Microbiology·M CoakleyC Stanton
Jan 21, 2004·The Journal of Biological Chemistry·Maria L AllendeRichard L Proia
Jul 16, 2004·The Journal of Clinical Investigation·Tomoko HayashiEyal Raz
Jan 3, 2006·American Journal of Respiratory and Critical Care Medicine·Peter EttmayerMaximilian Woisetschläger
Feb 18, 2006·Journal of Bacteriology·Peter KurdiAtsushi Yokota
Jun 21, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Maria L BelladonnaPaolo Puccetti
Dec 13, 2006·Transplant Immunology·Francesca FallarinoPaolo Puccetti
Mar 7, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Wen-Qi LaiBernard P Leung
Mar 26, 2008·Nature·Francisco J QuintanaHoward L Weiner
Jun 27, 2009·American Journal of Respiratory Cell and Molecular Biology·Fiorentina RoviezzoGiuseppe Cirino
Jun 18, 2010·Applied Microbiology and Biotechnology·Lara GorissenStefaan De Smet
Jul 21, 2010·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·R MacRedmondD R Dorscheid
Sep 15, 2010·Proceedings of the National Academy of Sciences of the United States of America·Jonathan R SwannElaine Holmes
Sep 24, 2010·The New England Journal of Medicine·Miriam F MoffattUNKNOWN GABRIEL Consortium
Apr 8, 2011·American Journal of Respiratory and Critical Care Medicine·Tina HerbstNicola L Harris
Aug 16, 2011·Gastroenterology·K B M Saiful IslamAtsushi Yokota
Aug 26, 2011·Journal of Pediatric Gastroenterology and Nutrition·Anders Daniel AndersenLotte Lauritzen
Jan 25, 2013·The Journal of Nutrition·Catarina D SimõesMaria Saarela
May 24, 2013·Science Translational Medicine·Tilla S WorgallStefan Worgall
Aug 31, 2013·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Laura B Fanning, Joshua A Boyce
Oct 16, 2013·Proceedings of the National Academy of Sciences of the United States of America·Shigenobu KishinoJun Ogawa
Jan 7, 2014·Nature Medicine·Aurélien TrompetteBenjamin J Marsland
Mar 14, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Marina MillerDavid H Broide
Aug 27, 2014·Frontiers in Immunology·Susanne V Schmidt, Joachim L Schultze
Jan 9, 2015·The Journal of Allergy and Clinical Immunology·Yvonne J Huang, Homer A Boushey
Feb 24, 2015·The British Journal of Nutrition·Tatiana M MarquesCatherine Stanton

❮ Previous
Next ❯

Citations

Oct 6, 2020·Frontiers in Pharmacology·Andrew J LeeMichael M Tunney
May 7, 2020·Metabolites·Kathleen A Lee-SarwarScott T Weiss
Mar 5, 2021·Frontiers in Immunology·William YipKelly M McNagny
Jun 3, 2021·Metabolites·Alma VillaseñorMaría M Escribese

❮ Previous
Next ❯

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Related Papers

Current Opinion in Cardiology
Yongzhong Zhao, Zeneng Wang
Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
J JungG-S Hwang
Reviews in Endocrine & Metabolic Disorders
Ben Arpad Kappel, Massimo Federici
Current Opinion in Rheumatology
Ariane R Panzer, Susan V Lynch
© 2021 Meta ULC. All rights reserved