Gut microbiome and microbial metabolites: a new system affecting metabolic disorders

Journal of Endocrinological Investigation
M Federici

Abstract

The gut microbiome is emerging as an important player in the field of metabolic disorders. Currently, several studies are ongoing to determine whether the effect of gut microbiome on obesity, type 2 diabetes, non-alcoholic fatty liver disease, and other metabolic diseases is determined by singular species or rather by a functional role of bacterial metabolism at higher taxonomical level. Deciphering if a single or more species are responsible for metabolic traits or rather microbial metabolic pathways are responsible for effects on host metabolism may help to identify appropriate dietary interventions to support microbial functions according to the prevalent host disease. Furthermore, the combination of metagenomics and metabolomics-based signature might be applied in the future to improve the risk prediction in healthy subjects. In this review, I will summarize the current findings regarding the role of gut microbiome and metabolites in metabolic disorders to argue whether the current achievements may be translated into clinical practice.

References

Jul 22, 2005·Proceedings of the National Academy of Sciences of the United States of America·Ruth E LeyJeffrey I Gordon
Dec 22, 2006·Nature·Ruth E LeyJeffrey I Gordon
Dec 22, 2006·Nature·Peter J TurnbaughJeffrey I Gordon
Apr 26, 2007·Diabetes·Patrice D CaniRémy Burcelin
Dec 2, 2008·Nature·Peter J TurnbaughJeffrey I Gordon
Dec 6, 2012·Nature Communications·Fredrik H KarlssonJens Nielsen
May 31, 2013·Nature·Fredrik H KarlssonFredrik Bäckhed
Aug 30, 2013·Nature·Emmanuelle Le ChatelierOluf Pedersen
Aug 30, 2013·Nature·Aurélie CotillardStanislav Dusko Ehrlich
Sep 7, 2013·Science·Vanessa K RidauraJeffrey I Gordon
Nov 12, 2015·Endocrine Connections·Lilit EgshatyanSergey Anatolyevic Boytsov
Jan 19, 2016·Nature Reviews. Endocrinology·Michelle T Long, Caroline S Fox
Jun 21, 2016·Cell Metabolism·Annika WahlströmFredrik Bäckhed
Jun 29, 2016·Nature Communications·Sushrut JangiHoward L Weiner
Jul 5, 2016·Cell Reports·Maria MavilioMassimo Federici
Jul 8, 2016·Nature·Justin L Sonnenburg, Fredrik Bäckhed
Jul 15, 2016·Nature·Helle Krogh PedersenOluf Pedersen
Aug 23, 2016·Digestive Diseases·Eleonora Scorletti, Christopher D Byrne
Aug 25, 2016·MBio·Marc A Sze, Patrick D Schloss
Dec 23, 2016·JAMA : the Journal of the American Medical Association·Anthony L Komaroff
Jan 8, 2017·Journal of Endocrinological Investigation·D Covelli, M Ludgate
Mar 8, 2017·Obesity Surgery·Dimitrios E MagouliotisDimitrios Zacharoulis
Jun 25, 2017·Atherosclerosis·Annika Lindskog JonssonGöran Bergström
Jul 27, 2017·Nature Reviews. Gastroenterology & Hepatology·Josephine NiVesselin T Tomov
Nov 7, 2017·Molecular Nutrition & Food Research·José María Moreno-NavarreteJosé Manuel Fernández-Real
Dec 1, 2017·Journal of Endocrinological Investigation·M G RadaelliG Perseghin
Jan 9, 2018·Nature Reviews. Microbiology·J Mark Brown, Stanley L Hazen
Jan 10, 2018·BMJ : British Medical Journal·Jose C ClementeJose U Scher
Mar 1, 2018·Nature·Daphna RothschildEran Segal
Mar 11, 2018·Clinical Science·Wei Ling LauNosratola D Vaziri
Mar 25, 2018·Circulation. Genomic and Precision Medicine·Deirdre K TobiasSamia Mora

❮ Previous
Next ❯

Citations

Jul 19, 2019·Expert Opinion on Drug Discovery·Yu DuBin Hong
Dec 15, 2019·Reviews in Endocrine & Metabolic Disorders·Ben Arpad Kappel, Massimo Federici
May 21, 2019·Current Opinion in Allergy and Clinical Immunology·Nonhlanhla LunjaniLiam O'Mahony
Feb 26, 2021·Frontiers in Molecular Biosciences·Meng Zhou, Jiang Zhao
Mar 24, 2021·Acta Diabetologica·Celine PomiéRémy Burcelin
May 2, 2021·International Journal of Biological Macromolecules·Emilia BonarBenedykt Wladyka
Nov 7, 2021·Molecular Medicine·Zixuan WangYan-Dong Wang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.