DOI: 10.1101/487652Dec 4, 2018Paper

Gut microbiome communication with bone marrow regulates susceptibility to amebiasis

BioRxiv : the Preprint Server for Biology
Stacey L BurgessWilliam A Petri

Abstract

The gut microbiome provides resistance to infection. However, the mechanisms for this are poorly understood. Colonization with the intestinal bacterium Clostridium scindens provided protection from the parasite Entamoeba histolytica via innate immunity. Introduction of C. scindens into the gut microbiota epigenetically altered and expanded bone marrow granulocyte-monocyte-progenitors (GMPs) and provided neutrophil-mediated protection against subsequent challenge with E. histolytica. Adoptive transfer of bone-marrow from C. scindens colonized-mice into naive-mice protected against ameba infection and increased intestinal neutrophils. Because of the known ability of C. scindens to metabolize the bile salt cholate, we measured deoxycholate and discovered that it was increased in the sera of C. scindens colonized mice, as well as in children protected from amebiasis. Administration of deoxycholate alone (in the absence of C. scindens) increased the epigenetic mediator JMJD3 and GMPs and provided protection from amebiasis. In conclusion the microbiota was shown to communicate to the bone marrow via microbially-metabolized bile salts to train innate immune memory to provide antigen-nonspecific protection from subsequent infection. Th...Continue Reading

Related Concepts

Amebiasis
Antigens
Bile Duct Structure
Bone Marrow
Disease Susceptibility
Entamoeba histolytica
Interleukin-6
Intestines
Laboratory mice
Neutrophil

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