Gut microbiome in chronic kidney disease

Experimental Physiology
Maria R WingDominic S Raj

Abstract

What is the topic of this review? This review addresses the contribution of the altered gut microbiome to uraemic syndrome, with specific reference to gut microbiome-derived uraemic toxins. It also discusses the potential treatment options to normalize the disturbed microbiome in chronic kidney disease (CKD). What advances does it highlight? This review highlights the importance of the gut-kidney connection and how the altered microbial landscape in the intestine contributes to dysmetabolism and inflammation in CKD. Recent findings linking gut-derived uraemic toxins to progression of CKD, cardiovascular disease and mortality are also discussed. Finally, we briefly explain targeted therapies that have been studied to restore intestinal symbiosis in CKD. The human intestine is now recognized as an important metabolic organ powered by gut microbiota. This review addresses the alteration in the gut microbiome in patients with chronic kidney disease (CKD) and its consequence. We describe the major uraemic toxins, p-cresol sulfate, indoxyl sulfate and trimethylamine N-oxide, which are produced by the gut microbiome, and how these metabolites contribute to progression of CKD and associated cardiovascular disease. Translocation of endo...Continue Reading

References

Aug 15, 1998·International Journal of Food Microbiology·W H HolzapfelJ H Huis in't Veld
Jun 29, 2002·Journal of the American Society of Nephrology : JASN·Atsushi EnomotoToshimitsu Niwa
Dec 4, 2003·Nephron. Experimental Nephrology·Masami SatohMasaru Motojima
Jul 21, 2004·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Ming-Ju WuMing-Jer Tang
Mar 28, 2006·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Gerald SchulmanNelson Kopyt
Oct 19, 2007·Nature·Peter J TurnbaughJeffrey I Gordon
Aug 30, 2008·PloS One·Zaruhi A KhachatryanRustam I Aminov
Aug 14, 2009·American Journal of Physiology. Renal Physiology·Hye Ryoun JangHamid Rabb
Aug 21, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Björn K I MeijersPieter Evenepoel
Aug 22, 2009·Clinical Journal of the American Society of Nephrology : CJASN·Fellype C BarretoUNKNOWN European Uremic Toxin Work Group (EUTox)
Aug 25, 2009·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Dominic S C RajKamyar Kalantar-Zadeh
Mar 6, 2010·Science·Matam Vijay-KumarAndrew T Gewirtz
May 1, 2010·Clinical Journal of the American Society of Nephrology : CJASN·Björn K I MeijersPieter Evenepoel
Aug 4, 2010·Proceedings of the National Academy of Sciences of the United States of America·Carlotta De FilippoPaolo Lionetti
Sep 18, 2010·Proceedings of the National Academy of Sciences of the United States of America·Les Dethlefsen, David A Relman
Oct 5, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·I-Wen WuMai-Szu Wu
Oct 12, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Iwao NakabayashiMasaharu Yoshida
May 4, 2011·Journal of Pharmaceutical Sciences·Hiroshi WatanabeToru Maruyama
Jul 26, 2011·Journal of the American Society of Nephrology : JASN·Pavel A AronovTimothy W Meyer
Sep 3, 2011·Science·Gary D WuJames D Lewis
Dec 2, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Nosratola D VaziriVeedamali S Subramanian
Apr 24, 2012·Gastroenterology·Gerhard WingenderMitchell Kronenberg
Sep 21, 2012·Kidney International·Nosratola D VaziriGary L Andersen
Oct 2, 2012·Clinical Journal of the American Society of Nephrology : CJASN·Jayanta GuptaUNKNOWN CRIC Study Investigators
Nov 7, 2012·American Journal of Nephrology·Nosratola D VaziriKamyar Kalantar-Zadeh
Feb 15, 2013·Science Translational Medicine·Xiaojiao ZhengWei Jia
Oct 31, 2013·Seminars in Immunology·Kristine A Kuhn, Thaddeus S Stappenbeck
Nov 16, 2013·Journal of the American Society of Nephrology : JASN·Ali Ramezani, Dominic S Raj
Jun 13, 2014·PloS One·Maria De AngelisLoreto Gesualdo
Oct 29, 2014·Journal of the American Society of Nephrology : JASN·Gerald SchulmanMiho Shimizu
Nov 25, 2014·Cell·Julia K GoodrichRuth E Ley
Jan 16, 2015·Journal of the American Society of Nephrology : JASN·Ian R BarrowsDominic S Raj
Jan 16, 2015·Journal of the American Society of Nephrology : JASN·Vinicius Andrade-OliveiraNiels Olsen Saraiva Câmara

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Citations

Apr 3, 2016·Experimental Physiology·Pedro A Jose
May 1, 2016·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Souhaila Al Khodor, Ibrahim F Shatat
Oct 21, 2016·The Journal of Infection·Nicola Principi, Susanna Esposito
May 13, 2017·Nutrients·Raul Fernandez-PradoMaria Dolores Sanchez-Niño
Sep 20, 2017·Journal of Clinical Medicine·Mohammed A I Al-ObaideTetyana L Vasylyeva
May 7, 2016·World Journal of Nephrology·Usama Abdel Azim Sharaf El DinDina Ossama Abdulazim
Oct 12, 2017·MBio·Katarzyna B Hooks, Maureen A O'Malley
Jul 2, 2017·Clinical Science·Jitske JansenRosalinde Masereeuw
Jul 16, 2019·Expert Opinion on Drug Safety·Nicola Principi, Susanna Esposito
Apr 14, 2017·Physiology·Sarah GallaBina Joe
Feb 8, 2019·Nature Reviews. Nephrology·Sanjay K Nigam, Kevin T Bush
Jan 4, 2019·Journal of Translational Medicine·Yuan-Yuan ChenYing-Yong Zhao
Jul 30, 2020·Curēus·Jemima C Stanley, Hong Deng
Feb 20, 2019·Diseases·Nima H JazaniNosratola D Vaziri
Mar 5, 2020·Saudi Journal of Kidney Diseases and Transplantation : an Official Publication of the Saudi Center for Organ Transplantation, Saudi Arabia·R VairakkaniT Yashwanth Raj
Oct 11, 2020·Physiological Reports·Oleg KaradutaBoris Zybailov
Jan 13, 2021·Journal of Clinical Medicine·Sylwia DudziczMarcin Adamczak
Mar 15, 2021·Nephrology·Peipei WangZhanzheng Zhao
Apr 16, 2021·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Wei LinHongtao Yang
May 20, 2021·Antioxidants & Redox Signaling·Thomas EbertPaul G Shiels
Nov 30, 2018·Dementia and Geriatric Cognitive Disorders Extra·Menizibeya O Welcome

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