Gut Microbiome in Inflammatory Bowel Disease and Other Chronic Immune-Mediated Inflammatory Diseases

Inflammatory Intestinal Diseases
Charles N Bernstein, Jessica D Forbes

Abstract

Since the description of the normal human gut microbiome in healthy individuals using broad-range polymerase chain reaction, there has been great advancement in the techniques used to conduct microbiome research and applications of this research across health, gastrointestinal diseases, and nongastrointestinal diseases. In inflammatory bowel disease (IBD), studies have reported gut dysbiosis meaning that the microbial composition, diversity, and richness are altered. Persons with IBD harbor on average 25% fewer microbial genes than healthy persons. Reduced diversity has been reported in both the fecal and mucosal microbiome of IBD. Crohn disease and ulcerative colitis are systemic diseases with immunological alterations in both intestinal and circulating compartments. As knowledge about the impact of the gut microbiome on the intestinal and systemic immune response has grown, researchers have begun exploring how the gut microbiome may impact on other systemic conditions. Considering the role of microbes especially on regulatory T cells, it was plausible that the gut microbiome may have a role in other chronic immune-mediated inflammatory diseases. In this review, studies of the gut microbiome in other chronic immune-mediated in...Continue Reading

References

Dec 26, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hanne R ChristensenJames J Pestka
Jun 3, 2004·Nature Reviews. Immunology·Andrew J Macpherson, Nicola L Harris
Aug 24, 2004·Infection and Immunity·Mairi C NoverrGary B Huffnagle
Mar 9, 2005·World Journal of Gastroenterology : WJG·Alexander SwidsinskiLaura-P Hale
Apr 16, 2005·Science·Paul B EckburgDavid A Relman
Oct 22, 2008·Proceedings of the National Academy of Sciences of the United States of America·Harry SokolPhilippe Langella
Oct 21, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Javier Ochoa-RepárazLloyd H Kasper
Dec 17, 2009·Applied and Environmental Microbiology·Laura L PresleyJames Borneman
Jul 22, 2010·The American Journal of Gastroenterology·Chin Wen PngTimothy H J Florin
Jul 29, 2010·Physiological Reviews·Inna SekirovB Brett Finlay
Oct 28, 2011·Nature·Kerstin BererGurumoorthy Krishnamoorthy
Aug 7, 2013·Nature Reviews. Genetics·Miles ParkesMatthew A Brown
Nov 25, 2014·Cell·Julia K GoodrichRuth E Ley
Dec 10, 2014·The American Journal of Gastroenterology·Charles N Bernstein
Feb 18, 2015·The Journal of Clinical Investigation·Emeran A MayerArpana Gupta
Mar 17, 2015·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·Brandi L CantarelEllen M Mowry
Dec 24, 2015·Frontiers in Immunology·Sushmita SinhaNitin J Karandikar
Mar 24, 2016·Journal of the Neurological Sciences·Helen TremlettUNKNOWN US Network of Pediatric MS Centers
May 14, 2016·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Helen TremlettUNKNOWN US Network of Pediatric MS Centers
Jun 28, 2016·Scientific Reports·Jun ChenAshutosh K Mangalam
Jun 29, 2016·Nature Communications·Sushrut JangiHoward L Weiner
Jul 28, 2016·Frontiers in Microbiology·Jessica D ForbesCharles N Bernstein
Sep 23, 2016·BMC Neurology·Helen TremlettUNKNOWN US Network of Pediatric MS Centers
Feb 22, 2017·Annals of Neurology·Helen TremlettEmmanuelle Waubant
Aug 15, 2017·Current Dermatology Reports·Di YanWilson Liao

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Citations

Dec 19, 2018·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Berkeley N LimketkaiAlyssa M Parian
Feb 23, 2019·Modern Rheumatology·Mitsuhiro AkiyamaTsutomu Takeuchi
Jun 25, 2019·The American Journal of Gastroenterology·Natalie C KnoxCharles N Bernstein
Sep 4, 2019·Nature Microbiology·Thomas C FungElaine Y Hsiao
Jun 7, 2019·Gut·Janine van der GiessenGwenny Manel Fuhler
Apr 28, 2020·Inflammatory Bowel Diseases·Anna KuballaDario Sorrentino
May 17, 2019·Terapevticheskiĭ arkhiv·N A DanilovaR A Abdulkhakov
Feb 26, 2019·Frontiers in Pharmacology·Francesco CappelloAlberto J L Macario
Oct 1, 2020·Microorganisms·Andrea Quagliariello All The Other Fmt Opbg Committee Collaborators
Jan 29, 2019·Frontiers in Microbiology·Jessica D ForbesNatalie C Knox
Oct 5, 2019·Mediators of Inflammation·Anshul Sinha, Corinne F Maurice
Oct 13, 2020·Scandinavian Journal of Gastroenterology·Dorit Vedel AnkersenPia Munkholm
Jan 28, 2021·Microorganisms·Milan JirkůKateřina Jirků-Pomajbíková
Jun 20, 2020·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·David M ChascsaTheo Heller
Apr 23, 2021·BMC Nephrology·Agni Nhirmal Kumar SugurmarRizna Abdul Cader

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