Gut Microbiome of Healthy and Arthritic Dogs

Veterinary Sciences
Michela CintioBruno Stefanon

Abstract

Several studies have underlined the interplay among host-microbiome and pathophysiological conditions of animals. Research has also focused specifically on whether and how changes in the gut microbiome have provoked the occurrence of pathological phenomena affecting cartilage and joints in humans and in laboratory animals. Here, we tried to evaluate the relationship between the gut microbiome and the hip and elbow arthritis in owned dogs. The study included 14 dogs suffering from chronic arthritis (AD) and 13 healthy dogs (HD). After the first visit and during the period of the study, the dogs, under the supervision of the owner, were fed a semi-moist complete diet supplemented with omega 3 fatty acids. Feces and blood samples were collected in the clinic at the first visit (T0) and after days (T45). The plasma C-reactive protein (CRP) was higher, and the serum vitamin B12 and folate concentrations were lower (p < 0.05) in the AD group in comparison to the HD group. Data of the fecal microbiome showed that the relative abundances of the genus Megamonas were higher in AD (p < 0.001), while the relative abundance of the families Paraprevotellaceae, Porphyromonadaceae, and Mogibacteriaceae was significantly lower in comparison to ...Continue Reading

References

Jan 15, 1990·Clinica Chimica Acta; International Journal of Clinical Chemistry·E E Kim, H W Wyckoff
Aug 1, 1989·Baillière's Clinical Rheumatology·K D Katz, D Hollander
Sep 5, 2002·Veterinary Surgery : VS·David JacquesGilles Dupre
Jun 9, 2004·The British Journal of Nutrition·Sylvia H DuncanHarry J Flint
Oct 7, 2004·Applied and Environmental Microbiology·Sylvia H DuncanHarry J Flint
Feb 23, 2007·Annals of the Rheumatic Diseases·S DahaghinH A P Pols
Nov 2, 2007·Alimentary Pharmacology & Therapeutics·H M HamerR-J Brummer
Nov 26, 2008·Nature Reviews. Immunology·Gökhan S Hotamisligil, Ebru Erbay
Apr 14, 2011·The Veterinary Clinics of North America. Small Animal Practice·Olivier Dossin, Rachel Lavoué
Jun 28, 2011·Genome Biology·Nicola SegataCurtis Huttenhower
Feb 22, 2012·Nature Reviews. Gastroenterology & Hepatology·Indrani MukhopadhyaGeorgina L Hold
Sep 4, 2012·Current Opinion in Biotechnology·Jean Guy LeBlancMarco Ventura
Dec 29, 2012·American Journal of Veterinary Research·Nora BerghoffJörg M Steiner
Feb 8, 2013·Journal of Cellular Physiology·Laura R McCabeRobert A Britton
Mar 29, 2014·Journal of Cellular Physiology·Robert A BrittonLaura R McCabe
Jun 3, 2014·BMC Veterinary Research·Hyung-Jin ParkKun-Ho Song
Aug 1, 2014·Behavioural Brain Research·S M O'MahonyJ F Cryan
Jan 7, 2015·World Journal of Gastroenterology : WJG·Giovanni TomaselloAngelo Leone
Mar 13, 2016·Joint, Bone, Spine : Revue Du Rhumatisme·Jean-Marie Berthelot, Pascal Claudepierre
Apr 17, 2016·Osteoarthritis and Cartilage·V B KrausP Mitchell
Jun 19, 2016·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Christopher J HernandezSteven R Goldring
Jun 28, 2016·Neurochemistry International·Roman M StillingJohn F Cryan
Apr 6, 2017·International Journal of Rheumatic Diseases·Saba FarnaghiIndira Prasadam
Oct 11, 2017·The Journal of Veterinary Medical Science·Marie OmoriNaoaki Matsuki
Nov 1, 2017·Journal of Agricultural and Food Chemistry·Minhao XieYi Sun
Nov 5, 2017·Current Rheumatology Reports·Christopher J Hernandez
Nov 5, 2017·Advances in Experimental Medicine and Biology·Darin Quach, Robert A Britton
Nov 21, 2017·Veterinary Medicine and Science·Ida N KielerCharlotte R Bjornvad

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Citations

Dec 10, 2020·Veterinary Sciences·Elisa ScarsellaBruno Stefanon
Aug 28, 2021·Animals : an Open Access Journal From MDPI·Inhwan You, Min Jung Kim

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Datasets Mentioned

BETA
PRJNA611632

Software Mentioned

R
Vegan
LEfSe
QIIME

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