Gut Microbiome Profiles Are Associated With Type 2 Diabetes in Urban Africans.

Frontiers in Cellular and Infection Microbiology
Ayo P DoumateyCharles N Rotimi

Abstract

Gut dysbiosis has been associated with several disease outcomes including diabetes in human populations. Currently, there are no studies of the gut microbiome composition in relation to type 2 diabetes (T2D) in Africans. Here, we describe the profile of the gut microbiome in non-diabetic adults (controls) and investigate the association between gut microbiota and T2D in urban West Africans. Gut microbiota composition was determined in 291 Nigerians (98 cases, 193 controls) using fecal 16S V4 rRNA gene sequencing done on the Illumina MiSeq platform. Data analysis of operational taxonomic units (OTU) was conducted to describe microbiome composition and identify differences between T2D and controls. The most abundant phyla were Firmicutes, Actinobacteria, and Bacteroidetes. Clostridiaceae, and Peptostreptococcaceaea were significantly lower in cases than controls (p < 0.001). Feature selection analysis identified a panel of 18 OTUs enriched in cases that included Desulfovibrio piger, Prevotella, Peptostreptococcus, and Eubacterium. A panel of 17 OTUs that was enriched in the controls included Collinsella, Ruminococcus lactaris, Anaerostipes, and Clostridium. OTUs with strain-level annotation showing the largest fold-change include...Continue Reading

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Citations

Sep 10, 2020·Infection and Immunity·Eric L BrownHerbert L DuPont
Feb 2, 2021·Current Osteoporosis Reports·Julie Kristine KnudsenSuzette Sørensen
Mar 3, 2021·European Journal of Nutrition·Yasaman GhorbaniJohane P Allard
Apr 4, 2021·International Journal of Molecular Sciences·Hideo YonezawaShigeru Kamiya
Apr 27, 2021·Frontiers in Endocrinology·M Nazmul HudaBrian J Bennett
May 4, 2021·Gut Microbes·Heidi L DodenJason M Ridlon
Jun 24, 2021·PloS One·Gertraud MaskarinecMeredith A J Hullar
Jul 16, 2021·Therapeutic Advances in Infectious Disease·Kristine M ErlandsonCara C Wilson

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Methods Mentioned

BETA
PCR
Phyloseq

Software Mentioned

USEARCH
Second Genome Solutions
DESeq2
mothur
MicrobiomeAnalyst
UPARSE
Phyloseq R
PERMANOVA
SecondGenomeR

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