Aug 17, 2019

Gut Microbiota Analysis in Postoperative Lynch Syndrome Patients

Frontiers in Microbiology
Giorgia MoriMaria Rosalia Pasca

Abstract

Lynch syndrome (LS) is a dominantly inherited condition with incomplete penetrance, characterized by high predisposition to colorectal cancer (CRC), endometrial and ovarian cancers, as well as to other tumors. LS is associated with constitutive DNA mismatch repair (MMR) gene defects, and carriers of the same pathogenic variants can show great phenotypic heterogeneity in terms of cancer spectrum. In the last years, human gut microbiota got a foothold among risk factors responsible for the onset and evolution of sporadic CRC, but its possible involvement in the modulation of LS patients' phenotype still needs to be investigated. In this pilot study, we performed 16S rRNA gene sequencing of bacterial DNA extracted from fecal samples of 10 postoperative LS female patients who had developed colonic lesions (L-CRC) or gynecological cancers (L-GC). Our preliminary data show no differences between microbial communities of L-CRC and L-GC patients, but they plant the seed of the possible existence of a fecal microbiota pattern associated with LS genetic background, with Faecalibacterium prausnitzii, Parabacteroides distasonis, Ruminococcus bromii, Bacteroides plebeius, Bacteroides fragilis and Bacteroides uniformis species being the most...Continue Reading

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Mentioned in this Paper

Ruminococcus bromii
Patterns
Magnetic Resonance Imaging
Genes
Malignant Neoplasm of Stomach
Endometrium
Bacteroides plebeius
Neoplasms
Pilot Projects
Bacteroides fragilis

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