Gut Microbiota and Bone Health

Advances in Experimental Medicine and Biology
Darin Quach, Robert A Britton

Abstract

The past decade has seen an explosion of research in the area of how the bacteria that inhabit the human body impact health and disease. One of the more surprising concepts to emerge from this work is the ability of the intestinal microbiota to impact virtually all systems in the body. Recently, the role of gut bacteria in bone health and disease has received more significant attention. In this chapter, we review what has been learned about how the gut microbiome impacts bone health and discuss possible mechanisms of how the gut-bone axis may be connected. We also discuss the use of therapeutic microbes in the modulation of bone health. Finally, we propose an emerging field of the gut-brain-bone axis, in which the gut drives bone physiology via regulation of key hormones that are originally synthesized in the brain.

Citations

Feb 18, 2018·Calcified Tissue International·Laura R McCabe, Narayanan Parameswaran
Dec 31, 2019·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Jonathan D SchepperLaura R McCabe
Jan 30, 2020·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Anna Cline-SmithRajeev Aurora
Aug 12, 2020·Journal of Clinical Laboratory Analysis·Chen ChenYu Zhu
Jun 20, 2020·Probiotics and Antimicrobial Proteins·Deon P Neveling, Leon M T Dicks
Mar 29, 2019·World Journal of Orthopedics·David Yatsonsky IiNabil A Ebraheim
Jul 18, 2020·Veterinary Sciences·Michela CintioBruno Stefanon
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Jan 16, 2021·Bone & Joint Research·Jie LiRonald Man Yeung Wong
Feb 16, 2021·Frontiers in Physiology·Scott EpsleyChamith S Rajapakse
Feb 2, 2021·Journal of Diabetes and Metabolic Disorders·Salman Shirvani RadMandana Hasanzad
May 30, 2021·BMC Complementary Medicine and Therapies·Nima Montazeri-NajafabadyAhmad Gholami
May 28, 2021·Frontiers in Nutrition·Qi Su, Qin Liu
Jun 9, 2021·Cell Proliferation·Leming JiaXin Xu
Jul 6, 2021·Journal of Diabetes and Metabolic Disorders·Shahrbanoo Keshavarz Azizi RaftarSeyed Davar Siadat
Apr 8, 2020·Aging and Disease·Kai DingWenge Ding

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