Gut Microbiota Are Disease-Modifying Factors After Traumatic Spinal Cord Injury

Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics
Kristina A KigerlPhillip G Popovich

Abstract

Spinal cord injury (SCI) disrupts the autonomic nervous system (ANS), impairing its ability to coordinate organ function throughout the body. Emerging data indicate that the systemic pathology that manifests from ANS dysfunction exacerbates intraspinal pathology and neurological impairment. Precisely how this happens is unknown, although new data, in both humans and in rodent models, implicate changes in the composition of bacteria in the gut (i.e., the gut microbiota) as disease-modifying factors that are capable of affecting systemic physiology and pathophysiology. Recent data from rodents indicate that SCI causes gut dysbiosis, which exacerbates intraspinal inflammation and lesion pathology leading to impaired recovery of motor function. Postinjury delivery of probiotics containing various types of "good" bacteria can partially overcome the pathophysiologal effects of gut dysbiosis; immune function, locomotor recovery, and spinal cord integrity are partially restored by a sustained regimen of oral probiotics. More research is needed to determine whether gut dysbiosis varies across a range of clinically relevant variables, including sex, injury level, and injury severity, and whether changes in the gut microbiota can predict ...Continue Reading

References

Oct 21, 2003·Autonomic & Autacoid Pharmacology·F MigniniF Amenta
Oct 27, 2004·Proceedings of the National Academy of Sciences of the United States of America·Fredrik BäckhedJeffrey I Gordon
Apr 16, 2005·Science·Paul B EckburgDavid A Relman
Jun 15, 2005·Archives of Physical Medicine and Rehabilitation·Patricia J MannsDaniel P Williams
Sep 16, 2005·Nature Reviews. Neuroscience·Christian MeiselUlrich Dirnagl
Jun 3, 2006·Science·Steven R GillKaren E Nelson
Dec 13, 2006·Nature Medicine·Christel RousseauxPierre Desreumaux
Dec 22, 2006·Nature·Peter J TurnbaughJeffrey I Gordon
Jan 11, 2007·Proceedings of the National Academy of Sciences of the United States of America·Fredrik BäckhedJeffrey I Gordon
Mar 23, 2007·Journal of Gastroenterology and Hepatology·Silvio BalzanIvan Cecconello
Apr 17, 2007·The European Journal of Neuroscience·Tino RieggerJan M Schwab
May 1, 2007·Archives of Physical Medicine and Rehabilitation·Mark P JensenDiane D Cardenas
Jun 5, 2007·Physical Medicine and Rehabilitation Clinics of North America·David R Gater
Sep 19, 2007·The Journal of Spinal Cord Medicine·Mindy Dopler NelsonCraig M McDonald
Feb 24, 2009·Proceedings of the National Academy of Sciences of the United States of America·William R WikoffGary Siuzdak
Jun 6, 2009·The Journal of Physiology·Peter J Turnbaugh, Jeffrey I Gordon
Jun 24, 2009·Journal of Neurochemistry·Kurt M LucinPhillip G Popovich
Aug 26, 2009·Rehabilitation Psychology·Mark P JensenAlyssa M Bamer
Sep 24, 2009·Journal of Neurotrauma·Jessica InskipAndrei Krassioukov
Nov 11, 2009·Current Opinion in Gastroenterology·Ruth E Ley
Mar 3, 2010·Annual Review of Immunology·David A Hill, David Artis
Apr 27, 2010·Journal of Rehabilitation Medicine·Kerstin WahmanRichard Levi
Jul 16, 2010·Nature Reviews. Neuroscience·Katharina WulffRussell G Foster
Jul 28, 2010·Proceedings of the National Academy of Sciences of the United States of America·Yun Kyung LeeSarkis K Mazmanian
Jul 29, 2010·Physiological Reviews·Inna SekirovB Brett Finlay
Aug 14, 2010·Microbiology·Cecilia JernbergJanet K Jansson
Sep 28, 2010·Metabolism: Clinical and Experimental·Ashraf S GorgeyDavid R Gater
Dec 25, 2010·Therapeutic Advances in Gastroenterology·Elizabeth C Verna, Susan Lucak
Mar 10, 2011·Annals of Neurology·Javier Ochoa-RepárazLloyd H Kasper
Jun 3, 2011·The Journal of Clinical Investigation·Herbert Tilg, Arthur Kaser
Jun 29, 2011·Proceedings of the National Academy of Sciences of the United States of America·Martin A KriegelDiane Mathis
Aug 2, 2011·Trends in Immunology·Irina B MazoUlrich H von Andrian
Oct 28, 2011·Nature·Kerstin BererGurumoorthy Krishnamoorthy
Jan 10, 2012·Annual Review of Immunology·Angelina M Bilate, Juan J Lafaille
Feb 1, 2012·Archives of Physical Medicine and Rehabilitation·Nirupama WijesuriyaAshley Craig
Apr 24, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Michael A OropalloMichael P Cancro
Jun 8, 2012·Science·Lora V HooperAndrew J Macpherson
Aug 2, 2012·Journal of Psychosomatic Research·Ashley CraigJames Middleton
Sep 13, 2012·Nature Reviews. Neuroscience·John F Cryan, Timothy G Dinan
Sep 25, 2012·Nature Reviews. Microbiology·Stephen M CollinsPremysl Bercik

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Citations

Dec 12, 2018·Nutritional Neuroscience·Hilal YildiranGizem Özata Uyar
Dec 14, 2018·Journal of Translational Medicine·Chao ZhangJianjun Li
Oct 11, 2019·Disease Models & Mechanisms·Claudia Figueroa-RomeroEva L Feldman
Aug 29, 2019·Expert Opinion on Therapeutic Targets·Shuo WangShuxin Li
Jun 13, 2020·Frontiers in Immunology·Trisha Jogia, Marc J Ruitenberg
Jun 12, 2020·World Journal of Gastroenterology : WJG·Marco BernardiTommaso Sciarra
Jan 18, 2018·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Javier Ochoa-Repáraz, Lloyd H Kasper
Oct 20, 2020·Brain Pathology·Omar Mossad, Daniel Erny
Jan 17, 2021·International Journal of Molecular Sciences·David DiazMelchor Alvarez-Mon
Jan 12, 2021·Neurobiology of Pain·Courtney A BannermanNader Ghasemlou
Dec 24, 2020·Journal of Neurotrauma·Leslie R MorseUNKNOWN SCI 2020 Working Group
Dec 22, 2019·Experimental Neurology·Matthew T Goodus, Dana M McTigue
Jan 5, 2021·JOR Spine·Xuhui LiuBernard Halloran
Dec 15, 2020·Nature Reviews. Neurology·Karim FouadJan M Schwab
Nov 13, 2020·Scientific Reports·Diane SuAileen J Anderson
Apr 4, 2021·Journal of Clinical Medicine·Jorge OjedaPía M Vidal
May 1, 2021·Frontiers in Nutrition·Joelle Leonie Flueck, Jill A Parnell
May 6, 2021·BMC Pediatrics·Ying ZhouWeibing Tang
Jul 3, 2021·Nutrients·Belinda RuettimannJoelle Leonie Flueck
Jul 6, 2021·Frontiers in Neuroscience·Arthur Sefiani, Cédric G Geoffroy

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