Gut microbiota, cannabinoid system and neuroimmune interactions: New perspectives in multiple sclerosis

Biochemical Pharmacology
L MestreC Guaza

Abstract

The gut microbiota plays a fundamental role on the education and function of the host immune system. Immunological dysregulation is the cause of numerous human disorders such as autoimmune diseases and metabolic disorders frequently associated with inflammatory processes therefore is critical to explore novel mechanisms involved in maintaining the immune system homeostasis. The cannabinoid system and related bioactive lipids participate in multiple central and peripheral physiological processes that affect metabolic, gastrointestinal and neuroimmune regulatory mechanisms displaying a modulatory role and contributing to the maintenance of the organism's homeostasis. In this review, we gather the knowledge on the gut microbiota-endocannabinoids interactions and their impact on autoimmune disorders such as inflammatory bowel disease, rheumatoid arthritis and particularly, multiple sclerosis (MS) as the best example of a CNS autoimmune disorder. Furthermore, we contribute to this field with new data on changes in many elements of the cannabinoid system in a viral model of MS after gut microbiota manipulation by both antibiotics and probiotics. Finally, we highlight new therapeutic opportunities, under an integrative view, targeting...Continue Reading

References

Jun 1, 1989·Journal of Neuroimmunology·W D LymanM B Bornstein
Nov 1, 1994·Immunopharmacology·I WirguinT Brenner
Feb 7, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·D BakerV Di Marzo
Oct 19, 2001·Gastroenterology·M D Van SickleK A Sharkey
Jan 5, 2002·Current Opinion in Pharmacology·A A IzzoF Capasso
Feb 25, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Belén G RamírezMaría L de Ceballos
Mar 8, 2005·Journal of Neurochemistry·Leyre MestreCarmen Guaza
Apr 16, 2005·The Journal of Pharmacology and Experimental Therapeutics·Arpád SzabóJános Szolcsányi
Jun 9, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Silvia Ortega-GutiérrezCarmen Guaza
Jan 25, 2006·Inflammatory Bowel Diseases·Harry SokolJoël Doré
Mar 31, 2006·Proceedings of the National Academy of Sciences of the United States of America·Anke WittingNephi Stella
Jun 20, 2006·Experimental and Molecular Pathology·N J BartonI P Chessell
Dec 13, 2006·Nature Medicine·Christel RousseauxPierre Desreumaux
Dec 22, 2006·Nature·Peter J TurnbaughJeffrey I Gordon
Mar 3, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Cristina BenitoJulián Romero
Jul 13, 2007·Brain : a Journal of Neurology·Diego CentonzeMauro Maccarrone
May 30, 2008·Nature·Sarkis K MazmanianDennis L Kasper
Aug 30, 2008·Neuropharmacology·Nephi Stella
Sep 11, 2008·Current Pharmaceutical Design·Diego CentonzeMauro Maccarrone
Nov 14, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ildiko RaczRafael Maldonado
Apr 4, 2009·Nature Reviews. Immunology·June L Round, Sarkis K Mazmanian
May 2, 2009·Inflammatory Bowel Diseases·Martin A StorrKeith A Sharkey
Aug 22, 2009·Journal of the Neurological Sciences·L Jean-GillesC S Constantinescu
Oct 20, 2009·Cell·Ivaylo I IvanovDan R Littman
Oct 21, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Javier Ochoa-RepárazLloyd H Kasper
Jun 23, 2010·Proceedings of the National Academy of Sciences of the United States of America·June L Round, Sarkis K Mazmanian
Jun 23, 2010·Proceedings of the National Academy of Sciences of the United States of America·Maria G Dominguez-BelloRob Knight

❮ Previous
Next ❯

Citations

Dec 14, 2019·Nature Reviews. Neurology·Luigia CristinoVincenzo Di Marzo
Jan 11, 2020·Frontiers in Pediatrics·Sara MatricardiAlberto Verrotti
May 29, 2020·Journal of Receptor and Signal Transduction Research·Nan ZhengDongkai Shan
Mar 20, 2019·Frontiers in Cellular and Infection Microbiology·Lianjun YangHai Lu
Oct 1, 2020·BMC Endocrine Disorders·Flavio A Cadegiani
Jun 18, 2020·International Journal of Molecular Sciences·Tomasz CharytoniukAdrian Chabowski
Feb 12, 2021·Journal of Neuroimmunology·Durga Shankar SharmaRavi Kumar Gutti
Mar 6, 2021·Neurobiology of Pain·Kieran ReaJohn F Cryan
Nov 11, 2021·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Nicholas DopkinsMitzi Nagarkatti

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Related Papers

Trends in Immunology
Gerard E Kaiko, Thaddeus S Stappenbeck
Current Opinion in Rheumatology
Mohamed K Bedaiwi, Robert D Inman
Clinical & Translational Immunology
Leandro A LoboAna Carolina Oliveira
© 2022 Meta ULC. All rights reserved