Gut microbiota characterisation in obese patients before and after bariatric surgery

Beneficial Microbes
G CampiscianoM Comar

Abstract

Intestinal microbiota analysis of obese patients after bariatric surgery showed that Proteobacteria decreased after laparoscopic sleeve gastrectomy (SG), while it increased after laparoscopic gastric bypass (LGB). Comparing to normal weight (NW) patients, obese patients that were selected for SG showed an almost equal amount of Firmicutes and Bacteroidetes and the ratio was not affected by the surgery. Obese patients before LGB showed a predominance of Bacteroidetes, whose amount regained a relative abundance similar to NW patients after surgery. Obese patients before LGB showed the predominance of Bacteroides, which decreased after surgery in favour of Prevotella, a bacterium associated with a healthy diet. The bacteria detected at the highest percentages belonged to biofilm forming species. In conclusion, in this study, we found that the characterization of the gut microbial communities and the modality of mucosal colonisation have a central role as markers for the clinical management of obesity and promote the maintenance of good health and the weight loss.

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Citations

Feb 23, 2019·Journal of Endocrinological Investigation·M Federici
Apr 7, 2020·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Elisa Morales-MarroquinSarah E Messiah
Oct 24, 2018·European Endocrinology·Arkiath V RaveendranJoseph M Pappachan
Apr 15, 2019·Obesity Surgery·Josianne C H B M LuijtenMisha D P Luyer
Jul 1, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Hanfei ZhuShuqin Zhu
Mar 7, 2019·Frontiers in Endocrinology·Mihai CovasaClaudiu Cobuz
Aug 8, 2019·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Silvia PalmisanoNicolò de Manzini
Jul 25, 2021·International Journal of Molecular Sciences·Chunye Zhang, Ming Yang
Aug 10, 2021·Therapeutic Advances in Gastrointestinal Endoscopy·Pierluigi PucaFranco Scaldaferri
Aug 8, 2021·Endocrine Reviews·Elina AkalestouCarel W le Roux

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