Gut Microbiota Composition in Mid-Pregnancy Is Associated with Gestational Weight Gain but Not Prepregnancy Body Mass Index

Journal of Women's Health
Anna-Katariina AatsinkiHasse Karlsson

Abstract

Pregnancy is a time of numerous hormonal, metabolic, and immunological changes for both the mother and the fetus. Furthermore, maternal gut microbiota composition (GMC) is altered during pregnancy. One major factor affecting GMC in pregnant and nonpregnant populations is obesity. The aim was to analyze associations between maternal overweight/obesity, as well as gestational weight gain (GWG) and GMC. Moreover, the modifying effect of depression and anxiety symptom scores on weight and GMC were investigated. Study included 46 women from the FinnBrain Birth Cohort study, of which 36 were normal weight, and 11 overweight or obese according to their prepregnancy body mass index (BMI). Stool samples were collected in gestational week 24, and the GMC was sequenced with Illumina MiSeq approach. Hierarchical clustering was executed to illuminate group formation according to the GMC. The population was divided according to Firmicutes and Bacteroidetes dominance. Symptoms of depression, general anxiety, and pregnancy-related anxiety were measured by using standardized questionnaires. Excessive GWG was associated with distinct GMC in mid-pregnancy as measured by hierarchical clustering and grouping according to Firmicutes or Bacteroidetes...Continue Reading

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Citations

Oct 23, 2019·Annual Review of Public Health·Audrey RensonJennifer B Dowd
Oct 6, 2020·American Journal of Physiology. Endocrinology and Metabolism·Biao WangWentao Wang
Feb 12, 2021·Journal of Applied Microbiology·Ebenezeri Erasto NgowiDong-Dong Wu
Dec 17, 2021·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Begoña de CuevillasSantiago Navas-Carretero

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Methods Mentioned

BETA
flow cytometry
Assay
PCR

Software Mentioned

QIIME
R vegan
R vegan package
UniFrac

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