Gut microbiota composition modulates inflammation and structure of the vagal afferent pathway.

Physiology & Behavior
J S KimC B de La Serre

Abstract

Vagal afferent neurons (VAN), located in the nodose ganglion (NG) innervate the gut and terminate in the nucleus of solitary tract (NTS) in the brainstem. They are the primary sensory neurons integrating gut-derived signals to regulate meal size. Chronic high-fat diet (HFD) consumption impairs vagally mediated satiety, resulting in overfeeding. There is evidence that HFD consumption leads to alterations in both vagal nerve function and structural integrity. HFD also leads to marked gut microbiota dysbiosis; in rodent models, dysbiosis is sufficient to induce weight gain. In this study, we investigated the effect of microbiota dysbiosis on gut-brain vagal innervation independently of diet. To do so, we recolonized microbiota-depleted rats with gastrointestinal (GI) contents isolated from donor animals fed either a HFD (45 or 60% fat) or a low fat diet (LFD, 13% fat). We used two different depletion models while maintaining the animals on LFD: 1) conventionally raised Fischer and Wistar rats that underwent a depletion paradigm using an antibiotic cocktail and 2) germ free (GF) raised Fischer rats. Following recolonization, receiver animals were designated as ConvLF and ConvHF. Fecal samples were collected throughout these studies...Continue Reading

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Citations

Apr 4, 2021·International Journal of Molecular Sciences·Manon LeclercFrédéric Calon
Apr 4, 2021·International Journal of Molecular Sciences·Jamie van SonMax Nieuwdorp
May 28, 2021·Heliyon·Marianela Andrea Díaz UrrutiaDaniela Miotto Bernardi

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