Gut Microbiota Contributes to Resistance Against Pneumococcal Pneumonia in Immunodeficient Rag-/- Mice

Frontiers in Cellular and Infection Microbiology
Krysta M FelixHsin-Jung Joyce Wu

Abstract

Streptococcus pneumoniae causes infection-related mortality worldwide. Immunocompromised individuals, including young children, the elderly, and those with immunodeficiency, are especially vulnerable, yet little is known regarding S. pneumoniae-related pathogenesis and protection in immunocompromised hosts. Recently, strong interest has emerged in the gut microbiota's impact on lung diseases, or the "gut-lung axis." However, the mechanisms of gut microbiota protection against gut-distal lung diseases like pneumonia remain unclear. We investigated the role of the gut commensal, segmented filamentous bacteria (SFB), against pneumococcal pneumonia in immunocompetent and immunocompromised mouse models. For the latter, we chose the Rag-/- model, with adaptive immune deficiency. Immunocompetent adaptive protection against S. pneumoniae infection is based on antibodies against pneumococcal capsular polysaccharides, prototypical T cell independent-II (TI-II) antigens. Although SFB colonization enhanced TI-II antibodies in C57BL/6 mice, our data suggest that SFB did not further protect these immunocompetent animals. Indeed, basal B cell activity in hosts without SFB is sufficient for essential protection against S. pneumoniae. However, ...Continue Reading

References

Mar 17, 2000·Immunological Reviews·P ZhangS Nelson
Apr 23, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·M Christine ThurnheerNicolaas A Bos
Apr 30, 2003·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Manuel L Fernández GuerreroMiguel de Górgolas
Dec 23, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Abdul Q KhanClifford M Snapper
Oct 16, 2008·Clinical Microbiology Reviews·Damiana ChiavoliniSusanna Ricci
Oct 9, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Alex C ChinCharles A Parkos
Oct 20, 2009·Cell·Ivaylo I IvanovDan R Littman
Jan 19, 2010·Nature Medicine·Thomas B ClarkeJeffrey N Weiser
Apr 9, 2010·Current Opinion in Pulmonary Medicine·Joseph P Lynch, George G Zhanel
Jun 23, 2010·The Journal of Experimental Medicine·Cristina L SwansonRaul M Torres
Aug 9, 2012·Chest·David H DockrellTimothy J Mitchell
Dec 4, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Zhen BianYuan Liu
May 1, 2013·American Journal of Respiratory and Critical Care Medicine·Desiree AnthonySteven Bozinovski
Oct 4, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Rudra BhowmickJohn M Leong
Nov 19, 2013·Immunity·Vincenzo Bronte, Mikael J Pittet
Feb 7, 2014·The New England Journal of Medicine·Richard G Wunderink, Grant W Waterer
Apr 30, 2014·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Katia De FilippoNancy Hogg
Oct 12, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Maria L BalmerAndrew J Macpherson
Mar 11, 2015·PLoS Neglected Tropical Diseases·Sarah A C FalcãoCamila I de Oliveira
May 15, 2015·Cell Host & Microbe·Kei E Fujimura, Susan V Lynch
Jul 29, 2015·Infection and Immunity·Stefanie GauguetGerald B Pier
Feb 19, 2016·Thorax·T Phuong QuanUNKNOWN Infections in Oxfordshire Research Database (IORD)
Oct 22, 2016·Clinical and Experimental Immunology·M NasiA Cossarizza
May 25, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jeremy P McAleerJay K Kolls
Jul 21, 2016·Nature·Yoko KojimaNicholas J Leeper

❮ Previous
Next ❯

Citations

May 8, 2020·Oxidative Medicine and Cellular Longevity·Yang LiuYanfeng Wang
Jul 28, 2020·Frontiers in Cellular and Infection Microbiology·Zhongyi ZhaoChuanmin Tao
Mar 12, 2020·Frontiers in Microbiology·Dapeng ZhangYibin Feng
Jun 13, 2020·Frontiers in Immunology·Trisha Jogia, Marc J Ruitenberg
May 12, 2021·Journal of Leukocyte Biology·Baichao YuYiwei Chu

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR
flow cytometry
ELISA
ELISAs
light microscopy

Software Mentioned

GraphPad
TreeStar
Prism
FlowJo
ImageJ

Related Concepts

Related Feeds

Bacterial Pneumonia (ASM)

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.

Bacterial Pneumonia

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.