Gut Microbiota Dysbiosis Associated With Altered Production of Short Chain Fatty Acids in Children With Neurodevelopmental Disorders.

Frontiers in Cellular and Infection Microbiology
Katarina BojovićMaja Tolinački

Abstract

While gut microbiota dysbiosis has been linked with autism, its role in the etiology of other neurodevelopmental disorders (NDD) is largely underexplored. To our knowledge this is the first study to evaluate gut microbiota diversity and composition in 36 children from the Republic of Serbia diagnosed with NDD and 28 healthy children. The results revealed an increased incidence of potentially harmful bacteria, closely related to Clostridium species, in the NDD patient group compared to the Control group: Desulfotomaculum guttoideum (P < 0.01), Intestinibacter bartlettii (P < 0.05), and Romboutsia ilealis (P < 0.001). On the other hand, significantly lower diversity of common commensal bacteria in the NDD group of patients was noticed. Enterococcus faecalis (P < 0.05), Enterococcus gallinarum (P < 0.01), Streptococcus pasteurianus (P < 0.05), Lactobacillus rhamnosus (P < 0.01) and Bifidobacteria sp. were detected in lower numbers of patients or were even absent in some NDD patients. In addition, butyrate-producing bacteria Faecalibacterium prausnitzii (P < 0.01), Butyricicoccus pullicaecorum (P < 0.05), and Eubacterium rectale (P = 0.07) were less frequent in the NDD patient group. In line with that, the levels of fecal short cha...Continue Reading

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Citations

Apr 4, 2021·Journal of Clinical Medicine·Jorge OjedaPía M Vidal
Apr 25, 2021·Neuroscience and Biobehavioral Reviews·Shoshana EitanJacob Kuempel
Jun 12, 2021·Frontiers in Immunology·Marcela Davoli-FerreiraKathy D McCoy
Aug 13, 2021·The Journal of Microbiology·Yaya ZhouXiaorong Wang
Aug 24, 2021·Current Opinion in Endocrine and Metabolic Research·Cheryl S Rosenfeld
Aug 28, 2021·Biomedicines·Mirko ManchiaBernardo Carpiniello
Aug 30, 2021·EBioMedicine·Saumya ShahYanjiao Zhou
Dec 3, 2021·Journal of Agricultural and Food Chemistry·Yong ZhangXiangyuan Wan

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Methods Mentioned

BETA
Electrophoresis
PCR
histone acetylation
biopsies

Software Mentioned

Chromeleon
GraphPad Prism
BLAST

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