Gut microbiota dysbiosis in polycystic ovary syndrome: association with obesity - a preliminary report.

Canadian Journal of Physiology and Pharmacology
Yuanjiao LiangTao Shen

Abstract

The objective was to explore if and how the microbiota changed in polycystic ovary syndrome (PCOS) women compared with healthy women. Eight obese PCOS (PO group), 10 nonobese PCOS (PN group), and nine healthy normal weight women (control) (C group) were enrolled. Insulin (INS), testosterone (T), follicle-stimulating hormone (FSH), luteinizing hormone (LH), estrogen (E2), and dehydroepiandrosterone (DHEA) were detected with radioimmunoassay. Antimullerian hormone (AMH), fasting glucose, and hemoglobin A1c (HbA1c) were determined by a chemiluminescence immunoassay, glucose oxidase method, and HPLC, respectively. Gut microbiota composition was evaluated by PCR. Alpha diversity was assessed using Chao1 and the Shannon index. PCOS women showed significantly higher T, LH, and LH/FSH and lower FSH levels than the C group (p < 0.05). The AMH level was significantly higher in the PO than in the PN group (p < 0.05). The PO group presented a significantly higher fasting INS level and HMOA-IR scores than the other groups, lower observed SVs and alpha diversity than the C group, higher beta diversity than the PN group (p < 0.05), and decreased abundances of genera (mainly butyrate producers). Regression analysis showed that decreased abunda...Continue Reading

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Citations

Jun 17, 2020·Critical Reviews in Food Science and Nutrition·Ricardo Wesley AlbercaMaria Notomi Sato
Jan 1, 2021·Journal of the Endocrine Society·Maryan G Rizk, Varykina G Thackray
Jan 8, 2021·Reproductive Sciences·Jingbo GuoJunping Hu
May 11, 2021·World Journal of Clinical Cases·Ioannis IliasLina Zabuliene
Mar 26, 2021·Journal of Neurogastroenterology and Motility·Kichul Yoon, Nayoung Kim
Oct 16, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Akari KusamotoYutaka Osuga

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