Gut microbiota, endotoxemia, inflammation, and oxidative stress in patients with heart failure, left ventricular assist device, and transplant.

The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation
Melana YuzefpolskayaRyan T Demmer

Abstract

Gut microbial imbalance may contribute to endotoxemia, inflammation, and oxidative stress in heart failure (HF). Changes occurring in the intestinal microbiota and inflammatory/oxidative milieu during HF progression and following left ventricular assist device (LVAD) or heart transplantation (HT) are unknown. We aimed to investigate variation in gut microbiota and circulating biomarkers of endotoxemia, inflammation, and oxidative stress in patients with HF (New York Heart Association, Class I-IV), LVAD, and HT. We enrolled 452 patients. Biomarkers of endotoxemia (lipopolysaccharide and soluble [sCD14]), inflammation (C-reactive protein, interleukin-6, tumor necrosis factor-α, and endothelin-1 adiponectin), and oxidative stress (isoprostane) were measured in 644 blood samples. A total of 304 stool samples were analyzed using 16S rRNA sequencing. Gut microbial community measures of alpha diversity were progressively lower across worsening HF class and were similarly reduced in patients with LVAD and HT (p < 0.05). Inflammation and oxidative stress were elevated in patients with Class IV HF vs all other groups (all p < 0.05). Lipopolysaccharide was elevated in patients with Class IV HF (vs Class I-III) as well as in patients with ...Continue Reading

Citations

Jul 28, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Bogdan DorofteiGabriela Simionescu
Aug 26, 2020·Translational Research : the Journal of Laboratory and Clinical Medicine·Yixin ZhangJie Du
Feb 10, 2021·Current Heart Failure Reports·Thanat Chaikijurajai, W H Wilson Tang
Dec 12, 2020·Journal of Molecular and Cellular Cardiology·Petra MamicW H Wilson Tang
May 25, 2021·The Journal of Clinical Hypertension·Pan WangJing Li
Sep 26, 2021·Current Opinion in Organ Transplantation·Yun Zhu BaiRuben G Nava

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