Gut microbiota in dementia. Critical review of novel findings and their potential application.

Progress in Neuro-psychopharmacology & Biological Psychiatry
Mateusz ŁucJoanna Rymaszewska

Abstract

There is a great deal of impetus for the comprehensive understanding of the complete pathological function, genetic information, and functional diversity of the gut microbiota that favors the development of dementia. It has been reported that patients with mild cognitive impairment and Alzheimer's disease present with several metabolic and immune-inflammatory alterations. The recently highlighted aspects of human health linked to cognitive decline include insulin-resistance, obesity, and chronic low-grade inflammation. Gut microbiota is known to produce neurotransmitters, such as GABA, acetylcholine, dopamine or serotonin, vitamins, intestinal toxins, and modulate nerve signaling - with emphasis on the vagus nerve. Additionally, gut dysbiosis results in impaired synthesis of signaling proteins affecting metabolic processes relevant to the development of Alzheimer's disease. Due to numerous links of gut microbiota to crucial metabolic and inflammatory pathways, attempts aimed at correcting the gut microflora composition may affect dementia pathology in a pleiotropic manner. Taking advantage of the metabolic effects of cold exposure on organisms by the introduction of whole-body cryostimulation in dementia patients could lead to ...Continue Reading

Citations

Mar 14, 2021·Progress in Neuro-psychopharmacology & Biological Psychiatry·Błażej MisiakIgor Łoniewski
May 1, 2021·International Journal of Molecular Sciences·Carlos M CuestaMaría Pascual
Jul 25, 2021·International Journal of Molecular Sciences·Javier Calleja-CondeJose Antonio López-Moreno

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