Gut microbiota in Parkinson disease in a northern German cohort

Brain Research
Franziska HopfnerGregor Kuhlenbäumer

Abstract

Pathologic and epidemiologic studies suggest that Parkinson disease (PD) may in some cases start in the enteric nervous system and spread via the vagal nerve to the brainstem. Mounting evidence suggests that the gut microbiome plays an important role in the communication between gut and brain and that alteration of the gut microbiome is involved in the pathogenesis of numerous diseases, including Parkinson disease. The aim of this study was to determine whether Parkinson disease is associated with qualitative or quantitative changes in the gut microbiome. We analyzed the gut microbiome in 29 PD cases and 29 age-matched controls by next-generation-sequencing of the 16S rRNA gene and compared diversity indices and bacterial abundances between cases and controls. Alpha diversity measures and the abundance of major phyla did not differ between cases and controls. Beta diversity analyses and analysis on the bacterial family level revealed significant differences between cases and controls for four bacterial families. In keeping with recently published studies, Lactobacillaceae were more abundant in cases. Barnesiellaceae and Enterococcacea were also more abundant in cases in this study but not in other studies. Larger studies, accou...Continue Reading

Citations

Mar 25, 2018·Movement Disorders : Official Journal of the Movement Disorder Society·Madelyn C HouserMalú G Tansey
Oct 19, 2017·Current Neurology and Neuroscience Reports·Eamonn M M Quigley
Dec 5, 2017·Current Behavioral Neuroscience Reports·Paula Perez-PardoAletta D Kraneveld
May 10, 2018·Journal of Innate Immunity·Kristina Endres, Karl-Herbert Schäfer
Aug 14, 2018·Beneficial Microbes·P Perez-PardoA D Kraneveld
Jun 22, 2018·Biological Research for Nursing·Michelle L WrightVicki Stover Hertzberg
Apr 6, 2019·Journal of Neural Transmission·Rezzak YilmazDaniela Berg
Jun 5, 2019·Journal of Movement Disorders·Han-Lin Chiang, Chin-Hsien Lin
May 2, 2019·Journal of Neurology·Michal LubomskiCarolyn M Sue
Dec 18, 2018·Environmental Microbiology·Nina RadisavljevicBarton Brett Finlay
Oct 15, 2019·Journal of Parkinson's Disease·Tomasz Brudek
Sep 10, 2019·Journal of Parkinson's Disease·Jeffrey M BoertienFilip Scheperjans
Oct 3, 2019·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Sarah M O'DonovanCora O'Neill
Feb 28, 2020·Microbial Cell Factories·Liang Shen
Aug 27, 2017·Movement Disorders : Official Journal of the Movement Disorder Society·Anna Heintz-BuschartPaul Wilmes
Jun 11, 2020·International Journal of Molecular Sciences·Bruno TiloccaViviana Greco
Feb 14, 2018·Movement Disorders : Official Journal of the Movement Disorder Society·Agata Mulak
Dec 24, 2018·Movement Disorders : Official Journal of the Movement Disorder Society·Michela BarichellaGianni Pezzoli
Dec 26, 2018·Journal of Parkinson's Disease·Honglei Chen, Beate Ritz
Mar 7, 2019·Frontiers in Genetics·Ting-Ting HuangShao-Hua Hu
Aug 17, 2019·Nutrients·Christa BoulosNicole Fakhoury-Sayegh
Jul 30, 2019·Frontiers in Molecular Neuroscience·Chunxiao LiYing Zhang
Nov 7, 2019·Nutritional Neuroscience·Vittorio Emanuele BianchiRizzi Laura
Jan 11, 2020·Frontiers in Neurology·Aeja JacksonAli Keshavarzian
Apr 25, 2020·Brain Sciences·Daniele PietrucciAlessandro Desideri
Sep 15, 2017·Current Opinion in Neurology·Moira MarizzoniGiovanni B Frisoni
Jun 9, 2018·Frontiers in Aging Neuroscience·Yiwei QianQin Xiao
Jun 25, 2018·Cell and Tissue Research·Kathleen Shannon, Pieter Vanden Berghe
May 10, 2019·Frontiers in Neuroscience·Emily FitzgeraldHolly A Martinson
May 28, 2019·Nature Reviews. Gastroenterology & Hepatology·Boushra DalileKristin Verbeke
Jan 2, 2019·BMC Bioinformatics·Ko AbeTeppei Shimamura

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