Gut microbiota mediated benefits of barley kernel products on metabolism, gut hormones, and inflammatory markers as affected by co-ingestion of commercially available probiotics: a randomized controlled study in healthy subjects

Clinical Nutrition ESPEN
Anne NilssonInger Björck

Abstract

Barley kernel based products have been shown to induce benefits on blood glucose regulation, cardio-metabolic risk markers and appetite regulating hormones in a time perspective of 11-16 h after intake. The mechanisms have been assigned to gut fermentation of indigestible carbohydrates. The purpose of the present study was to evaluate if the modulatory effects of barley on markers of metabolic- and appetite regulation are affected by a dietary background including a mixture of commercially available probiotics. Barley kernel bread was included in the normal diet of 21 healthy subjects in two 4-day intervention periods; with (BB-pro) or without (BB) dietary supplement with a combination of probiotics (Bifidobacterium animalis DN-173 010, Lactobacillus reuteri DSM 17938, and Lactobacillus plantarum 299v). A white wheat flour based bread was included as a reference product (WWB-ref) in a separate 4-day bread intervention period. A cross-over design was applied concerning BB- and WWB-ref; the BB-pro intervention was last in the test sequence. The BB-pro intervention was preceded by 10 days priming with probiotics. The 4 day BB- and WWB-ref intervention periods included dietary supplementation with placebo, and the interventions wer...Continue Reading

Associated Clinical Trials

Citations

Apr 23, 2020·Oxidative Medicine and Cellular Longevity·Yawen ZengJiazhen Yang
Mar 7, 2019·Frontiers in Endocrinology·Mihai CovasaClaudiu Cobuz
Nov 15, 2017·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Gilliard LachJohn F Cryan
Aug 10, 2021·Beneficial Microbes·E Arvidsson NordströmN Larsson

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