Gut microbiota-mediated protection against diarrheal infections

Journal of Travel Medicine
Stefanie L Vogt, B Brett Finlay

Abstract

The mammalian gut microbiota is a highly abundant and diverse microbial community that resides in the gastrointestinal tract. One major benefit that the gut microbiota provides to its host is colonization resistance-the ability to prevent colonization by foreign microbes, including diarrheal pathogens such as Clostridium difficile , Salmonella enterica serovar Typhimurium and diarrheagenic Escherichia coli . We conducted a literature review of the effects of the gut microbiota on infection by diarrheal pathogens. We used PubMed to search for relevant articles published before July 2016, as well as incorporated data from our laboratory. The gut microbiota provides protection from diarrheal infections both by direct inhibition of pathogens and by indirect effects on host functions. Direct effects of the microbiota on diarrheal pathogens include competing for nutrients and producing metabolites that inhibit pathogen growth or virulence. Indirect effects of the gut microbiota include promoting maintenance of the gut mucosal barrier and stimulating innate and adaptive immunity. Human epidemiological studies and experimental infections of laboratory animals both demonstrate that antibiotic treatment can alter the gut microbial commun...Continue Reading

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Citations

Jan 20, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Paphavee LertsethtakarnCarl J Mason
Nov 22, 2018·Journal of Travel Medicine·Mark S Riddle, Bradley A Connor
Nov 1, 2017·Journal of Travel Medicine·Joseph Torresi, Robert Steffen
Jan 1, 2020·The FEBS Journal·Hari PrasadSandhya Srikant Visweswariah
Feb 28, 2020·Experimental and Therapeutic Medicine·Jinsong YangWenchang Zhang
Apr 18, 2018·Infection and Immunity·D T BolickR L Guerrant
Oct 16, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Fernanda L Paganelli, Miquel B Ekkelenkamp
Oct 17, 2018·Frontiers in Microbiology·Meng XuYujuan Shen
Nov 28, 2020·Microbial Cell Factories·Taha BaghbaniHamed Haddad Kashani
May 4, 2021·Frontiers in Cellular and Infection Microbiology·Yunxia LiYulong Yin
Aug 17, 2021·AMB Express·Lulu YangGuven Ozdemir

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