Gut microbiota modulation: a novel strategy for prevention and treatment of colorectal cancer.

Oncogene
Winnie FongJun Yu

Abstract

Research about the role of gut microbiome in colorectal cancer (CRC) is a newly emerging field of study. Gut microbiota modulation, with the aim to reverse established microbial dysbiosis, is a novel strategy for prevention and treatment of CRC. Different strategies including probiotics, prebiotics, postbiotics, antibiotics, and fecal microbiota transplantation (FMT) have been employed. Although these strategies show promising results, mechanistically by correcting microbiota composition, modulating innate immune system, enhancing gut barrier function, preventing pathogen colonization and exerting selective cytotoxicity against tumor cells, it should be noted that they are accompanied by risks and controversies that can potentially introduce clinical complications. During bench-to-bedside translation, evaluation of risk-and-benefit ratio, as well as patient selection, should be carefully performed. In view of the individualized host response to gut microbiome intervention, developing personalized microbiome therapy may be the key to successful clinical treatment.

References

Jun 1, 1995·The Journal of Nutrition·G R Gibson, M B Roberfroid
Oct 28, 1999·FEMS Immunology and Medical Microbiology·E M TuomolaS J Salminen
Dec 16, 2004·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·J P CannonL H Danziger
Apr 14, 2005·International Journal of Cancer. Journal International Du Cancer·Hideki IshikawaTadao Kakizoe
May 10, 2005·The British Journal of Nutrition·Maria Luisa Forchielli, W Allan Walker
Oct 6, 2005·Applied and Environmental Microbiology·Domitille Fayol-MessaoudiAlain L Servin
Apr 25, 2006·Journal of Clinical Gastroenterology·Julia M W WongDavid J A Jenkins
Jun 3, 2006·Science·Steven R GillKaren E Nelson
Sep 14, 2006·Cancer Biology & Therapy·Mark S GeierGordon S Howarth
Feb 8, 2007·The American Journal of Clinical Nutrition·Joseph RafterJohn K Collins
Mar 14, 2007·World Journal of Gastroenterology : WJG·P DeliaG Famularo
Aug 16, 2008·International Journal of Cancer. Journal International Du Cancer·Annamari KilkkinenPaul Knekt
Oct 15, 2008·Applied Microbiology and Biotechnology·O GillorM A Riley
Feb 19, 2010·Biomedical and Environmental Sciences : BES·Chang LiuXiao-Kui Guo
Jul 29, 2010·Physiological Reviews·Inna SekirovB Brett Finlay
Feb 2, 2011·Proceedings of the National Academy of Sciences of the United States of America·Mansour MohamadzadehTodd R Klaenhammer
Feb 18, 2011·Gut Microbes·Mary Ellen SandersElaine Vaughan
Mar 2, 2011·Nature Reviews. Microbiology·Benjamin P WillingB Brett Finlay
Apr 8, 2011·World Journal of Gastroenterology : WJG·Roberto Berni CananiAntonio Calignano
Sep 15, 2011·Biochimica Et Biophysica Acta·Melissa J PuppaJames A Carson
Jun 13, 2012·Proceedings of the National Academy of Sciences of the United States of America·Khashayarsha KhazaieMansour Mohamadzadeh
Jun 14, 2012·PLoS Pathogens·Seong Gyu JeonKiyoshi Takeda
Sep 26, 2012·Nature Reviews. Immunology·Todd R KlaenhammerMaria Rescigno
Jul 25, 2013·Frontiers in Microbiology·Miguel GueimondeAbelardo Margolles
Sep 7, 2013·Science·Vanessa K RidauraJeffrey I Gordon

❮ Previous
Next ❯

Citations

Sep 25, 2020·Nature·Alina JanneyElizabeth H Mann
Aug 6, 2020·International Journal of Molecular Sciences·Federica PerilloFederica Facciotti
Oct 8, 2020·Reviews in Endocrine & Metabolic Disorders·Marco GalloM C Zatelli
Nov 21, 2020·Future Microbiology·Harika NalluriChristopher Staley
Jan 7, 2021·American Journal of Physiology. Gastrointestinal and Liver Physiology·Roy HajjarManuela M Santos
Dec 30, 2020·International Journal of Biological Macromolecules·Ying SunPeifang Weng
Nov 17, 2020·Frontiers in Immunology·Muhammad IrfanJorge Frias-Lopez
Dec 18, 2020·Frontiers in Immunology·Yiwen ChengLanjuan Li
Dec 29, 2020·Frontiers in Cellular and Infection Microbiology·Yean Leng LokeSuat Cheng Peh
Dec 31, 2020·Nutrients·Giuseppe MerraAntonino De Lorenzo
Jan 26, 2021·Oxidative Medicine and Cellular Longevity·Sujuan DingGang Liu
Jan 21, 2021·Cancers·Stefania De SantisMarcello Chieppa
Feb 3, 2021·International Journal of Molecular Sciences·Giorgia Mori, Maria Rosalia Pasca
Feb 22, 2021·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Shu-Wei HuangFeng-Huei Lin
Mar 19, 2021·Molecular Systems Biology·Michael ZimmermannLisa Maier
Apr 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Nikola VrzáčkováJaroslav Zelenka
Apr 4, 2021·Biomedicines·Ali MohamedIrina V Pinchuk
Apr 2, 2021·Frontiers in Oncology·Ke LuHongbo Chen
May 1, 2021·International Journal of Molecular Sciences·Valerio FulciClaudia Carissimi
Jun 4, 2021·Probiotics and Antimicrobial Proteins·Sevinç Karaçam, Sinem Tunçer
May 22, 2021·Seminars in Cancer Biology·Mohd SaeedFarrukh Aqil
Jun 25, 2021·World Journal of Gastrointestinal Oncology·Antonio BiondiMarco Vacante
Jun 6, 2021·Clinics and Research in Hepatology and Gastroenterology·Youxin ZhouYuting Kuang
Jul 16, 2021·British Journal of Cancer·K A LeeT D Spector
Jun 4, 2021·Journal of Internal Medicine·Jiangwei SunFang Fang
Aug 6, 2021·Stem Cells International·Jintao YuanFei Mao
Aug 8, 2021·Cancers·Rozana Abdul RahmanMairéad G McNamara
Aug 14, 2021·Frontiers in Nutrition·Tarkan KarakanGwendolyn Janssen-van Solingen
Aug 18, 2021·Applied Microbiology and Biotechnology·Huazhen LuYanan Li

❮ Previous
Next ❯

Methods Mentioned

BETA
genetic modification

Clinical Trials Mentioned

NCT01410955
NCT03705442
NCT01839721
NCT03742596
NCT02313519
NCT03782428
NCT04021589
NCT04131803
NCT01579591
NCT03341143

Related Concepts

Related Feeds

Bacteriotherapy (ASM)

Bacteriotherapy, also known as fecal transplantation, involves the transfer of stool from a healthy donor into the gastrointestinal tract for the purpose of treating recurrent C. difficile colitis. Here is the latest on bacteriotherapy.

Bacteriotherapy

Bacteriotherapy, also known as fecal transplantation, involves the transfer of stool from a healthy donor into the gastrointestinal tract for the purpose of treating recurrent C. difficile colitis. Here is the latest on bacteriotherapy.

Related Papers

Journal of Gastroenterology and Hepatology
Sedigheh Taghinezhad-SXiangsheng Fu
Gastroenterology and Hepatology From Bed to Bench
Somayeh Jahani-SherafatHajieh Ghasemian-Safaei
Microbiology Spectrum
Terence Van Raay, Emma Allen-Vercoe
Clinics in Colon and Rectal Surgery
Grace Y Chen
© 2022 Meta ULC. All rights reserved