Gut microbiota: novel therapeutic target for nonalcoholic fatty liver disease

Expert Review of Gastroenterology & Hepatology
Ki Tae Suk, Dong Joon Kim

Abstract

Nonalcoholic fatty liver disease (NAFLD) is one of the most common and increasing liver diseases worldwide with a prevalence of 20-33%. NAFLD may progress to fibrosis, compensated cirrhosis, advanced cirrhosis, or hepatocellular carcinoma. Despite the increasing prevalence of NAFLD, definitive medical treatment has not been established, with the exception of lifestyle modification with exercise. Because of the direct connection via portal vein between the intestines and the liver (gut-gut microbiota-liver axis), gut microbiota and associated dysbiosis have been known as regulators in the pathophysiology of NAFLD. Area covered: New therapeutic approaches for modulation of gut microbiota have been proposed and the effectiveness of new therapies including probiotics, prebiotics, synbiotics, bile acid regulation, absorbent, and fecal microbiota transplantation have been demonstrated in recent several studies. This review focuses on the available evidences for new therapies modulating gut microbiota in the management and the prevention of NAFLD. Expert commentary: Gut-gut microbiota-liver axis may play an important role in the etiology of many liver diseases, including NAFLD. It is logical to seek the manipulation of this axis, and ...Continue Reading

References

Jan 1, 1987·Scandinavian Journal of Gastroenterology·S LoftP B Andreasen
Jan 19, 2000·The American Journal of Gastroenterology·A De SantisC De Simone
Feb 7, 2001·The American Journal of Clinical Nutrition·N M Delzenne, N Kok
Dec 14, 2002·Journal of Hepatology·Antoni MasUNKNOWN Spanish Association for the Study of the Liver Hepatic Encephalopathy Cooperative Group
Jan 24, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Zhiping LiAnna Mae Diehl
Jan 25, 2003·Annual Review of Biochemistry·David W Russell
Aug 28, 2004·Clinics in Liver Disease·Arthur J McCullough
Nov 13, 2004·Annals of Internal Medicine·Edgar R MillerEliseo Guallar
Nov 22, 2005·Journal of Lipid Research·Jason M RidlonPhillip B Hylemon
Feb 28, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Arun J SanyalAlan S Mills
Aug 10, 2006·Proceedings of the National Academy of Sciences of the United States of America·Marc-Emmanuel DumasJeremy K Nicholson
Nov 16, 2006·Liver International : Official Journal of the International Association for the Study of the Liver·Manfred BilzerAlexander L Gerbes
Jun 5, 2007·Clinics in Liver Disease·E Bugianesi
Nov 29, 2007·The ISME Journal·Cecilia JernbergJanet K Jansson
Jan 12, 2008·World Journal of Gastroenterology : WJG·Wan-Chun WuSheng Li
Jan 17, 2008·The Journal of Toxicological Sciences·Kiyoshi NagataShuhei Sakaguchi
Apr 9, 2008·Journal of Hepatology·Ina BergheimStephan C Bischoff
Apr 10, 2008·Liver International : Official Journal of the International Association for the Study of the Liver·Ashkan FarhadiAli Keshavarzian
May 10, 2008·European Journal of Gastroenterology & Hepatology·Márcia M AranhaCecília M P Rodrigues
Aug 2, 2008·Nature Reviews. Drug Discovery·Charles ThomasKristina Schoonjans
Sep 2, 2008·Proceedings of the National Academy of Sciences of the United States of America·Brian V JonesJulian R Marchesi
Dec 2, 2008·Nature·Peter J TurnbaughJeffrey I Gordon
Mar 18, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Luca MieleAntonio Grieco
Mar 20, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Manal F AbdelmalekUNKNOWN Nonalcoholic Steatohepatitis Clinical Research Network
Apr 30, 2010·The New England Journal of Medicine·Arun J SanyalUNKNOWN NASH CRN
Sep 4, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jasmohan S Bajaj, Oliviero Riggio
Oct 6, 2010·The British Journal of Nutrition·Marcel RoberfroidAgnes Meheust
Dec 15, 2010·The American Journal of Clinical Nutrition·Swaroop PendyalaPeter R Holt
Jan 15, 2011·American Journal of Physiology. Gastrointestinal and Liver Physiology·Timea CsakGyongyi Szabo
May 17, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Yanfei ChenLanjuan Li
Jun 21, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Neeraj BhalaJacob George
Jul 13, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Claudia O ZeinArthur J McCullough
Sep 3, 2011·Science·Gary D WuJames D Lewis
Sep 9, 2011·Digestive Diseases and Sciences·Michele MalaguarneraFabio Galvano
Sep 24, 2011·American Journal of Physiology. Gastrointestinal and Liver Physiology·Jasmohan S BajajPatrick M Gillevet
May 2, 2012·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·D CompareG Nardone
Jun 16, 2012·Nature·Tanya YatsunenkoJeffrey I Gordon

❮ Previous
Next ❯

Citations

May 8, 2019·Microorganisms·Haripriya GuptaKi Tae Suk
Sep 8, 2020·Expert Review of Gastroenterology & Hepatology·Letícia F RamosKaren C M Moraes
May 12, 2020·World Journal of Gastroenterology : WJG·Hui-Ting ChenYong-Jian Zhou
Dec 5, 2020·BioMed Research International·Kai ZhanShaogang Huang
Jan 1, 2021·International Journal of Molecular Sciences·Na Young Lee, Ki Tae Suk
Mar 4, 2021·International Journal of Molecular Sciences·Alessandro Mantovani, Andrea Dalbeni
Mar 23, 2021·Critical Reviews in Food Science and Nutrition·Ayfer Beyaz Coşkun, Adviye Gülçin Sağdiçoğlu Celep
Jun 1, 2021·Expert Review of Clinical Immunology·Jin ImaiNobuhiko Kamada
Jul 13, 2021·Journal of Agricultural and Food Chemistry·Chenyu XueJiali Wang
Sep 3, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Chang LiuJian Wu
Nov 20, 2020·European Journal of Gastroenterology & Hepatology·Yishu TangFang Cui

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bacteriotherapy (ASM)

Bacteriotherapy, also known as fecal transplantation, involves the transfer of stool from a healthy donor into the gastrointestinal tract for the purpose of treating recurrent C. difficile colitis. Here is the latest on bacteriotherapy.

Bacteriotherapy

Bacteriotherapy, also known as fecal transplantation, involves the transfer of stool from a healthy donor into the gastrointestinal tract for the purpose of treating recurrent C. difficile colitis. Here is the latest on bacteriotherapy.

Related Papers

Microbiology Spectrum
Anne-Marie CassardGabriel Perlemuter
Best Practice & Research. Clinical Gastroenterology
Tanvir R Haque, A Sidney Barritt
MMW Fortschritte der Medizin
Peter C KonturekYurdagül Zopf
© 2022 Meta ULC. All rights reserved