Gut microbiota regulate tumor metastasis via circRNA/miRNA networks.

Gut Microbes
Zhuxian ZhuZiqiang Zhang

Abstract

Increasing evidence indicates that gut microbiota plays an important role in cancer progression. However, the underlying mechanism remains largely unknown. Here, we report that broad-spectrum antibiotics (ABX) treatment leads to enhanced metastasis by the alteration of gut microbiome composition. Cancer LLC and B16-F10 cell metastasis mouse models, and microarray/RNA sequencing analysis were used to reveal the regulatory functions of microbiota-mediated circular RNA (circRNA)/microRNA (miRNA) networks that may contribute to cancer metastasis. The specific pathogen-free (SPF) mice with ABX treatment demonstrated enhanced lung metastasis. Fecal microbiota transplantation (FMT) from SPF mice or Bifidobacterium into germ-free mice significantly suppressed lung metastasis. Mechanistically, gut microbiota impacts circRNA expression to regulate levels of corresponding miRNAs. Specifically, such modulations of gut microbiota inhibit mmu_circ_0000730 expression in an IL-11-dependent manner. Bioinformatics analysis combined with luciferase reporter assays revealed reciprocal repression between mmu_circ_0000730 and mmu-miR-466i-3p. We further showed that both mmu-miR-466i-3p and mmu-miR-466 f-3p suppresses a number of genes involved in ep...Continue Reading

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Citations

Jan 5, 2021·Frontiers in Bioengineering and Biotechnology·Yuxin RanHongbo Qi
Jan 10, 2021·Trends in Microbiology·Nilusha Malmuthuge, Le Luo Guan
Mar 26, 2021·Journal of Cancer Research and Clinical Oncology·Qinglin WangQixing Mao
May 4, 2021·Frontiers in Oncology·Na FangYi-Jun Shi
Jul 27, 2021·Frontiers in Pharmacology·Jing ZhouSimin Chen
Aug 18, 2021·Applied Microbiology and Biotechnology·Huazhen LuYanan Li
Aug 28, 2021·Cells·Xianhui ZengJinhang Gao

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Datasets Mentioned

BETA
GSE140339
GSE140338
GSE140885
GSE140886
SRP226777

Methods Mentioned

BETA
pulldown
pull-down
RNA-seq
flow cytometry
chip
FACS
PCR
Protein Assay
immunoprecipitation
electrophoresis

Software Mentioned

Aksomics
CircNet
GraphPad Prism
FastQC
RNA 22v2
GeneSpring
GenePix Pro
TargetScan
R

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