Gut Movements: A Review of the Physiology of Gastrointestinal Transit

Digestive Diseases and Sciences
Dennis Kumral, Alvin M Zfass

Abstract

The well-regulated mechanisms of intestinal transit favor aboral movement of intestinal contents during the formation of normal stool. Electrical pacemakers initiate mechanical smooth muscular propulsion under regulation by the enteric nervous system-a function of the "brain-gut axis." Several unique intestinal motor patterns function in concert to enhance the activities of intestinal transit. Development of pharmacologic targets of intestinal transit mechanisms afford clinicians control in the management of functional gastrointestinal disorders. This review highlights the important physiologic events of intestinal transit, discusses selected pharmacologic and neuromodulators involved in these processes, and provides relevant clinical correlates to physiologic events.

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Citations

May 5, 2020·The Proceedings of the Nutrition Society·Benjamin CrooksJohn T McLaughlin
Feb 26, 2020·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Loyane Almeida GamaMadileine Francely Américo
Jun 3, 2021·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·M P R MachadoM F Américo
Sep 25, 2021·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Enid E MartinezNilesh M Mehta

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