Gut nutrient sensing and microbiota function in the control of energy homeostasis

Current Opinion in Clinical Nutrition and Metabolic Care
Gilles Mithieux

Abstract

To analyze the respective roles of macronutrient-derived moieties, of a gut mucosal function [intestinal gluconeogenesis (IGN)] and its capacity of influencing the brain control of energy homeostasis, and of the microbiota 'function' versus 'genomic composition' in the control of host metabolism. Small products deriving from protein digestion (peptides) or from fermentation by the gut microbiota (short-chain fatty acids and succinate) activate IGN, a mucosal function sensed by the peripheral gut nervous system, which intitiates metabolic benefits deriving from brain control of energy homeostasis. The microbiota function (fermentation) rather than its genomic composition is a key in these processes. Short-chain fatty acids and succinate produced from the fermentation of macronutrients by the gut microbiota positively influence the brain's control of energy homeostasis via the activation of IGN. The microbiota function rather than genomic composition is a key in these processes.

References

Dec 2, 2008·Nature·Peter J TurnbaughJeffrey I Gordon
Dec 18, 2013·Nature·Lawrence A DavidPeter J Turnbaugh
Jul 15, 2016·Cell Metabolism·Filipe De VadderGilles Mithieux
Aug 25, 2016·MBio·Marc A Sze, Patrick D Schloss
Nov 20, 2016·Experimental Physiology·Matúš SotákRobert J Unwin
Mar 18, 2017·Molecular Systems Biology·Simon NicolasMatteo Serino
Jun 8, 2017·Cell Metabolism·Maud SotyGilles Mithieux

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Citations

Aug 9, 2019·The International Journal of Biochemistry & Cell Biology·Christos Chinopoulos
Jan 26, 2021·The Canadian Journal of Infectious Diseases & Medical Microbiology = Journal Canadien Des Maladies Infectieuses Et De La Microbiologie Médicale·Ruiqi Tang, Lanjuan Li
Sep 17, 2021·Frontiers in Cellular and Infection Microbiology·Feng ZhaoXianjun Wang

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