Gut-residing segmented filamentous bacteria drive autoimmune arthritis via T helper 17 cells.

Immunity
Hsin-Jung WuDiane Mathis

Abstract

Commensal microbes can have a substantial impact on autoimmune disorders, but the underlying molecular and cellular mechanisms remain largely unexplored. We report that autoimmune arthritis was strongly attenuated in the K/BxN mouse model under germ-free (GF) conditions, accompanied by reductions in serum autoantibody titers, splenic autoantibody-secreting cells, germinal centers, and the splenic T helper 17 (Th17) cell population. Neutralization of interleukin-17 prevented arthritis development in specific-pathogen-free K/BxN mice resulting from a direct effect of this cytokine on B cells to inhibit germinal center formation. The systemic deficiencies of the GF animals reflected a loss of Th17 cells from the small intestinal lamina propria. Introduction of a single gut-residing species, segmented filamentous bacteria, into GF animals reinstated the lamina propria Th17 cell compartment and production of autoantibodies, and arthritis rapidly ensued. Thus, a single commensal microbe, via its ability to promote a specific Th cell subset, can drive an autoimmune disease.

References

Jun 1, 1992·FEMS Microbiology Reviews·H L KlaasenA C Beynen
Nov 18, 1989·BMJ : British Medical Journal·D P Strachan
Apr 1, 1993·Laboratory Animals·H L KlaasenA C Beynen
May 1, 1993·Immunology Today·P PozzilliP E Beales
Nov 29, 1996·Cell·V KouskoffD Mathis
Mar 16, 2002·Nature Immunology·Isao MatsumotoChristophe Benoist
Mar 22, 2002·Nature Reviews. Immunology·M Wills-KarpC L Karp
Apr 17, 2002·The Journal of Experimental Medicine·Mariana MaccioniDiane Mathis
Jun 3, 2004·Nature Reviews. Immunology·Andrew J Macpherson, Nicola L Harris
Mar 26, 2005·Science·Fredrik BäckhedJeffrey I Gordon
Jan 31, 2006·Nature Immunology·Bryce A BinstadtChristophe Benoist
Oct 7, 2006·Nature Reviews. Immunology·Sarkis K Mazmanian, Dennis L Kasper
Jul 25, 2007·The Journal of Experimental Medicine·Hsin-Jung WuDiane Mathis
Nov 10, 2007·Proceedings of the National Academy of Sciences of the United States of America·Daniel H D GrayDiane Mathis
May 24, 2008·Science·Ruth E LeyJeffrey I Gordon
Aug 20, 2008·Nature Immunology·Hekla Sigmundsdottir, Eugene C Butcher
Sep 17, 2008·Nature Reviews. Microbiology·Ruth E LeyJeffrey I Gordon
Dec 23, 2008·Mucosal Immunology·S Rakoff-Nahoum, R Medzhitov
Feb 4, 2009·The Journal of Clinical Investigation·David BendingAnne Cooke
Mar 18, 2009·Diabetes·Juliet A EmamaulleeA M James Shapiro
May 30, 2009·Science·Elizabeth A GriceJulia A Segre
Aug 18, 2009·Cell Host & Microbe·Alicia BensonFelix Yarovinsky
Sep 22, 2009·Immunity·Breck A DuerkopLora V Hooper
Oct 20, 2009·Cell·Ivaylo I IvanovDan R Littman
Oct 27, 2009·Nature Immunology·Nita H SalzmanNicolaas A Bos
Dec 4, 2009·Proceedings of the National Academy of Sciences of the United States of America·Jonathan P JacobsDiane Mathis
Dec 18, 2009·Nature Immunology·Alexander V Chervonsky
Feb 24, 2010·Proceedings of the National Academy of Sciences of the United States of America·Haochu HuangDiane Mathis

❮ Previous
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Citations

Sep 4, 2012·Seminars in Immunopathology·Taylor FeehleyCathryn R Nagler
Nov 1, 2011·Zeitschrift für Rheumatologie·H-D Chang, T Kamradt
Feb 11, 2012·Acta Neuropathologica·Kerstin Berer, Gurumoorthy Krishnamoorthy
Aug 14, 2012·Current Allergy and Asthma Reports·Irene FungMildred Kwan
Nov 18, 2011·Clinical Reviews in Allergy & Immunology·Graham A W Rook
Jun 22, 2012·Clinical Reviews in Allergy & Immunology·Rita A MouraJoão E Fonseca
May 7, 2013·Trends in Immunology·Yasmine BelkaidTimothy W Hand
Aug 27, 2013·Trends in Immunology·Kevin P Walsh, Kingston H G Mills
Oct 31, 2013·Seminars in Immunology·Kristine A Kuhn, Thaddeus S Stappenbeck
Dec 17, 2014·Clinical & Translational Immunology·Vahid FarrokhiRobert B Clark
Jan 16, 2013·Immunology and Cell Biology·Yoshiyuki Goto, Ivaylo I Ivanov
Oct 22, 2010·Mucosal Immunology·P D SmithS M Wahl
Sep 28, 2012·Mucosal Immunology·C L ThompsonA Brune
Jun 17, 2011·Nature·Andrew L KauJeffrey I Gordon
Sep 14, 2012·Nature·Craig L MaynardCasey T Weaver
Jun 15, 2011·Nature Immunology·Javier Rangel-MorenoTroy D Randall
Aug 28, 2012·Nature Immunology·Vaibhav UpadhyayYang-Xin Fu
Sep 20, 2012·Nature Immunology·Romina S Goldszmid, Giorgio Trinchieri
Jun 20, 2013·Nature Immunology·Yasmine Belkaid, Shruti Naik
Sep 21, 2013·Nature Immunology·Thomas F GajewskiYang-Xin Fu
Dec 21, 2010·Nature Immunology·Kendle M Maslowski, Charles R Mackay
Jan 10, 2012·Nature Medicine·Vijay K KuchrooCarola G Vinuesa
Jan 10, 2012·Nature Medicine·Hartmut WekerleDavid Serreze
May 9, 2012·Nature Medicine·Namiko Hoshi, Ruslan Medzhitov
Sep 9, 2011·Nature Medicine·Daniel J Cua, Jonathan P Sherlock
Sep 25, 2010·Nature Reviews. Immunology·Nadine Cerf-Bensussan, Valérie Gaboriau-Routhiau
Dec 15, 2010·Nature Reviews. Immunology·Maya Saleh, Giorgio Trinchieri
Sep 24, 2011·Nature Reviews. Immunology·Ruslan MedzhitovAnne O'Garra
Nov 19, 2011·Nature Reviews. Immunology·Kingston H G Mills
Mar 16, 2013·Nature Reviews. Immunology·Ludvig M Sollid, Bana Jabri
Apr 27, 2013·Nature Reviews. Immunology·Nobuhiko KamadaGabriel Núñez
Nov 3, 2010·Nature Reviews. Rheumatology·Alan Ebringer
Feb 4, 2011·Nature Reviews. Rheumatology·Clemens Scheinecker, Josef S Smolen
Aug 25, 2011·Nature Reviews. Rheumatology·Jose U Scher, Steven B Abramson
Aug 22, 2012·Nature Reviews. Rheumatology·William P Arend, Gary S Firestein
Apr 30, 2013·Médecine sciences : M/S·Nicolas BouladouxYasmine Belkaid
Jun 29, 2011·Proceedings of the National Academy of Sciences of the United States of America·Martin A KriegelDiane Mathis
Jan 2, 2013·Proceedings of the National Academy of Sciences of the United States of America·Ei WakamatsuChristophe Benoist
Aug 25, 2011·The Journal of Biological Chemistry·Kyoko TakahashiShuichi Kaminogawa

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