PMID: 2484589Jul 1, 1989Paper

Gut retention of metals in rats

Biological Trace Element Research
K KostialM Landeka

Abstract

In sucklings, a high fraction of orally administered metals and radionuclides is retained in the gut. The location of elements in the gut is of interest because of their potential local health effect. The purpose of this work was to evaluate the influence of chelation therapy on gut retention and location of cadmium, mercury, and cerium in suckling rats. Radionuclides 115mCd, 203Hg, and 141Ce were administered orally to 6-d-old rats. Chelating agent Zn-DTPA (3.64 mmol/kg) was administered to animals that received 115mCd or 141Ce and Na-DMPS (375 mumols/kg) to those that received 203Hg, immediately and 24 h or 24 and 48 h after radionuclide administration. Radioactivity was determined in the whole body and gastrointestinal tract 6 d later. Both early and delayed chelation treatment very effectively reduced whole body retention, and this was mainly owing to reduced gut retention. Although chelation therapy reduced gut retention of administered radionuclides 3-30 times, the site of metal accumulation and retention in the intestine remained unchanged. For all 3 radionuclides, both after early and delayed therapy, the site of metal accumulation was always the lower part of small intestine-ileum.

References

Feb 1, 1979·Environmental Health Perspectives·K KostialI Rabar
Aug 1, 1977·Toxicology and Applied Pharmacology·L B Sasser, G E Jarboe
Feb 1, 1987·Archives of Toxicology·B KargacinM Landeka
Nov 1, 1987·Toxicology Letters·K KostialM Landeka
Feb 1, 1972·Health Physics·J Inaba, F W Lengemann
Jun 1, 1983·Environmental Research·K KostialM Landeka

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Citations

Jan 12, 2011·Biological Trace Element Research·Keiko OhnishiKoichi Kono
Apr 1, 1992·Pharmacology & Toxicology·J B NielsenO Andersen
Sep 1, 1994·Environmental Health Perspectives·O AndersenL Scherrebeck
Mar 1, 1996·Environmental Health Perspectives·S Hirano, K T Suzuki
Mar 6, 2008·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Masami KawagoeToshihiro Sugiyama
Sep 25, 2001·Environmental Health Perspectives·W R McGinnis
Aug 4, 2001·Environmental Health Perspectives·D R Roberts
Jul 3, 2021·International Journal of Environmental Research and Public Health·Tariq IqbalXu Zhou

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