GWAS-Based Discoveries in IgA Nephropathy, Membranous Nephropathy, and Steroid-Sensitive Nephrotic Syndrome.

Clinical Journal of the American Society of Nephrology : CJASN
Elena Sanchez-RodriguezKrzysztof Kiryluk

Abstract

Over the past decade, genome-wide association studies (GWAS) have emerged as a powerful tool to understand the genetic basis of complex traits in humans. The GWAS approach has been successfully applied to primary glomerular disorders, providing numerous novel insights into the genetic architecture of IgA nephropathy, membranous nephropathy, and steroid-sensitive nephrotic syndrome. IgA nephropathy appears to have a highly complex polygenic architecture, with nearly 20 genome-wide significant loci of small-to-moderate effects discovered to date. In contrast, the genetic susceptibility to membranous nephropathy and steroid-sensitive nephrotic syndrome appears to be driven by a small number of large-effect loci. The MHC locus on chromosome 6p21 is strongly associated with genetic susceptibility to all major types of immune-mediated glomerulopathies. However, a distinct set of classical HLA alleles is associated with each individual disease type, pinpointing to specific immune mechanisms underlying each of these conditions. Additional insights from the discovery of non-HLA risk loci reinforced the role of innate and adaptive immunity in the pathogenesis of these disorders, and highlighted important susceptibility overlaps between g...Continue Reading

References

May 17, 2001·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·J A KariG J Snodgrass
Jun 28, 2002·The New England Journal of Medicine·Hanna DebiecPierre M Ronco
Feb 28, 2004·Proceedings of the National Academy of Sciences of the United States of America·Emanuela CastigliRaif S Geha
Jun 10, 2005·Human Molecular Genetics·Patricia M R AldredJohn A L Armour
Feb 15, 2008·Journal of the American Society of Nephrology : JASN·Ali G GharaviBruce A Julian
Apr 25, 2009·Nephron. Clinical Practice·Yuan-Yuan HuangJoung-Liang Lan
Jul 3, 2009·The New England Journal of Medicine·Laurence H BeckDavid J Salant
Jul 3, 2010·Journal of the American Society of Nephrology : JASN·John FeehallyPeter J Ratcliffe
Nov 12, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Anita McGroganCorinne S de Vries
Feb 18, 2011·The New England Journal of Medicine·Horia C StanescuRobert Kleta
Mar 15, 2011·Nature Genetics·Ali G GharaviRichard P Lifton
Sep 29, 2011·Journal of the American Society of Nephrology : JASN·Hitoshi SuzukiBruce A Julian
Dec 16, 2011·Immunological Reviews·Robert I Lehrer, Wuyuan Lu
Jan 17, 2012·American Journal of Human Genetics·Peter M VisscherJian Yang
Jul 3, 2013·Journal of the American Society of Nephrology : JASN·Jicheng LvHong Zhang
Nov 23, 2013·Clinical Journal of the American Society of Nephrology : CJASN·Gemma BullichElisabet Ars
Jun 4, 2014·The Journal of Clinical Investigation·Krzysztof Kiryluk, Jan Novak
Oct 29, 2014·Journal of the American Society of Nephrology : JASN·Rasheed A GbadegesinUNKNOWN Mid-West Pediatric Nephrology Consortium
Nov 14, 2014·The New England Journal of Medicine·Nicola M TomasGérard Lambeau
Feb 20, 2015·Journal of the American Society of Nephrology : JASN·Nicolas MaillardJan Novak
Jun 2, 2015·Nature Communications·Ming LiJian-Jun Liu
Sep 17, 2015·Kidney International·Riccardo MagistroniKrzysztof Kiryluk
Dec 18, 2015·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Raja RamachandranVivekanand Jha
Mar 5, 2016·Journal of the American Society of Nephrology : JASN·Jingyuan XieAli G Gharavi
Jun 23, 2016·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Peggy SekulaAnna Köttgen
Jul 1, 2016·Science Translational Medicine·Zhen AiXueqing Yu
Nov 18, 2016·Journal of the American Society of Nephrology : JASN·Zhao CuiMing-Hui Zhao
Dec 13, 2016·Journal of Medical Genetics·Bjarke FeenstraMads Melbye
Dec 29, 2016·Journal of the American Society of Nephrology : JASN·Wei-Bo LeZhi-Hong Liu
Feb 18, 2017·Journal of the American Society of Nephrology : JASN·Daniel P GaleJonathan Barratt
Jul 8, 2017·American Journal of Human Genetics·Peter M VisscherJian Yang
Nov 11, 2017·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Sanjana GuptaRobert Kleta
Dec 27, 2017·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Adebowale AdeyemoRasheed Gbadegesin
Jun 19, 2018·Lancet·Damien G NooneRulan Parekh
Jul 18, 2018·Journal of the American Society of Nephrology : JASN·Xiaoyuan JiaUNKNOWN Research Consortium on Genetics of Childhood Idiopathic Nephrotic Syndrome in Japan
Nov 14, 2018·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Laura H MarianiUNKNOWN CureGN Consortium
May 8, 2019·Journal of the American Society of Nephrology : JASN·Sanjeev SethiPierre Ronco
Jul 3, 2019·Journal of the American Society of Nephrology : JASN·Stephanie DufekDetlef Bockenhauer
Jan 7, 2020·Kidney International·Sanjeev SethiPierre Ronco

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Citations

Apr 10, 2021·Seminars in Immunopathology·Roman David BülowJulio Saez-Rodriguez
Oct 7, 2021·Cell and Tissue Research·Peter F ZipfelChristine Skerka

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