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GWAS for systemic sclerosis identifies multiple risk loci and highlights fibrotic and vasculopathy pathways

Nature Communications

Nov 2, 2019

Elena López-IsacJavier Martin

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Abstract

Systemic sclerosis (SSc) is an autoimmune disease that shows one of the highest mortality rates among rheumatic diseases. We perform a large genome-wide association study (GWAS), and meta-analysis with previous GWASs, in 26,679 individuals and identify 27 independent genome-wide associa...read more

Mentioned in this Paper

Biochemical Pathway
Meta Analysis (Statistical Procedure)
Genome
Genes
Autoimmune Diseases
ELOVL1
Subtype (Attribute)
Analysis
Fibrosis
Genetic Loci
35
1
26
1
Paper Details
References
  • References61
  • Citations1
12345...
  • References61
  • Citations1
1

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Systemic sclerosis (SSc)

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GWAS for systemic sclerosis identifies multiple risk loci and highlights fibrotic and vasculopathy pathways

Nature Communications

Nov 2, 2019

Elena López-IsacJavier Martin

PMID: 31672989

DOI: 10.1038/s41467-019-12760-y

Abstract

Systemic sclerosis (SSc) is an autoimmune disease that shows one of the highest mortality rates among rheumatic diseases. We perform a large genome-wide association study (GWAS), and meta-analysis with previous GWASs, in 26,679 individuals and identify 27 independent genome-wide associa...read more

Mentioned in this Paper

Biochemical Pathway
Meta Analysis (Statistical Procedure)
Genome
Genes
Autoimmune Diseases
ELOVL1
Subtype (Attribute)
Analysis
Fibrosis
Genetic Loci
35
1
26
1

Feeds With Similar Papers

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

General Biology Journal eTOCs

Discover the latest general biology research in this collection of the top biology journals.

Related Papers

Nihon rinsho. Japanese journal of clinical medicine

Systemic sclerosis (SSc)

Nihon rinsho. Japanese journal of clinical medicineFebruary 13, 2002
Osamu Ishikawa, Kazunori Ohnishi
Paper Details
References
  • References61
  • Citations1
12345...
  • References61
  • Citations1
1

Download from

Publisher
PubMed
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