Gynaecologic challenging issues in the management of BRCA mutation carriers: oral contraceptives, prophylactic salpingo-oophorectomy and hormone replacement therapy

Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology
Angiolo GadducciAndrea Riccardo Genazzani

Abstract

BRCA1 and BRCA2 mutation carriers have a 54-85% and 45% lifetime risk of developing breast cancer, respectively, and a 18-60% and 11-27% lifetime risk of developing ovarian cancer, respectively. Oral contraceptives (OCs) significantly reduce the risk of ovarian cancer also in BRCA1/BRCA2 mutation carriers. The association between OC use and breast cancer risk in these women is controversial. Some studies showed a modestly increased risk especially among BRCA1 mutation carriers. The risk appears to be greater for women who took OCs for at least 5 years and who took OCs before the age of 30 years. Other studies reported that duration of use before first full-term pregnancy has a positive association with breast cancer risk. Salpingo-oophorectomy reduces the risk of coelomic epithelial cancer of 80-95% and the risk of breast cancer of approximately 50%. BRCA1 and BRCA2 mutation carriers should be encouraged to undergo prophylactic bilateral salpingo-oophorectomy at the age of 35-40 years or when childbearing is complete. Short-term use of hormone replacement therapy may relieve menopausal symptoms and does not appear to affect the breast cancer risk reduction obtained with salpingo-oophorectomy.

References

Jan 1, 1983·Medical Decision Making : an International Journal of the Society for Medical Decision Making·J R Beck, S G Pauker
Apr 10, 1995·American Journal of Medical Genetics·M J SellerG S Tint
Oct 1, 1995·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·D Rothacker, G Möbius
Jan 1, 1996·Annual Review of Pharmacology and Toxicology·J D Yager, J G Liehr
Oct 9, 1998·Obstetrics and Gynecology·C A BanderaS C Mok
Oct 17, 1998·Journal of the Society for Gynecologic Investigation·G C RodriguezC L Hughes
Apr 21, 1999·International Journal of Cancer. Journal International Du Cancer·C MagnussonI Persson
Sep 2, 1999·Journal of the National Cancer Institute·T R RebbeckB L Weber
Feb 5, 2000·JAMA : the Journal of the American Medical Association·C SchairerR Hoover
Feb 17, 2000·Journal of the National Cancer Institute·R K RossM C Pike
Apr 29, 2000·Gynecologic Oncology·P G RoseG L Wiesner
Aug 30, 2000·Journal of the National Cancer Institute. Monographs·E CavalieriD Roy
Oct 23, 2001·International Journal of Cancer. Journal International Du Cancer·J RoyarJ Chang-Claude
Jan 5, 2002·Journal of the National Cancer Institute·Joellen M SchildkrautGustavo C Rodriguez
Jan 5, 2002·Journal of the National Cancer Institute·Gustavo C RodriguezClaude L Hughes
May 25, 2002·The New England Journal of Medicine·Noah D KauffKenneth Offit
May 25, 2002·The New England Journal of Medicine·Timothy R RebbeckUNKNOWN Prevention and Observation of Surgical End Points Study Group
Jun 28, 2002·The New England Journal of Medicine·Polly A MarchbanksLinda K Weiss
Jul 19, 2002·JAMA : the Journal of the American Medical Association·Jacques E RossouwUNKNOWN Writing Group for the Women's Health Initiative Investigators
Dec 5, 2002·Journal of the National Cancer Institute·Steven A NarodJean-Sebastien Brunet
Jan 31, 2003·British Journal of Cancer·M D AlthuisL A Brinton
May 27, 2003·International Journal of Cancer. Journal International Du Cancer·Vanessa DumeauxEiliv Lund
Aug 15, 2003·International Journal of Cancer. Journal International Du Cancer·Laura M NewcomerE Robert Greenberg
Oct 2, 2003·Journal of the National Cancer Institute·William D FoulkesLars A Akslen
Oct 25, 2003·Science·Mary-Claire KingUNKNOWN New York Breast Cancer Study Group
Oct 30, 2003·Journal of Cellular Physiology·Sherri L StewartChristos Patriotis
Nov 15, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Douglas A LevineJeff Boyd
Nov 19, 2003·The Journal of Steroid Biochemistry and Molecular Biology·W YueE L Cavalieri
Dec 4, 2003·Annals of the New York Academy of Sciences·E DeligeoroglouG Creatsas
Feb 26, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Katrina ArmstrongBarbara Weber
Apr 15, 2004·JAMA : the Journal of the American Medical Association·Garnet L AndersonUNKNOWN Women's Health Initiative Steering Committee
Apr 24, 2004·American Journal of Obstetrics and Gynecology·Ronald BurkmanMiriam Zieman
Nov 17, 2004·British Journal of Cancer·A S WhittemoreM S Piver
Nov 20, 2004·International Journal of Cancer. Journal International Du Cancer·Agnès FournierFrançoise Clavel-Chapelon
Mar 1, 2005·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Roger L MilneAlice S Whittemore

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Citations

Mar 29, 2016·The Breast : Official Journal of the European Society of Mastology·Shani Paluch-ShimonFatima Cardoso
Sep 12, 2013·Obstetrics and Gynecology Clinics of North America·Dana Meaney-Delman, Cecelia A Bellcross
Jun 12, 2012·Contraception·Ashlesha PatelUNKNOWN Society of Family Planning
Apr 29, 2014·The Breast : Official Journal of the European Society of Mastology·Ann H PartridgeFatima Cardoso
Jan 31, 2014·Clinical Journal of Oncology Nursing·Suzanne M Mahon
Dec 4, 2014·The Breast : Official Journal of the European Society of Mastology·Esther Molina-MontesMaría-José Sánchez
Jul 19, 2016·Climacteric : the Journal of the International Menopause Society·F Guidozzi
Nov 3, 2016·Journal of Cancer Education : the Official Journal of the American Association for Cancer Education·Ariane Santerre-TheilUNKNOWN Centre ROSE
Sep 18, 2018·BJOG : an International Journal of Obstetrics and Gynaecology·Cmg van DrielM J Mourits
Oct 26, 2016·Menopause : the Journal of the North American Menopause Society·Elizabeth A HiblerDavid S Alberts
Nov 21, 2013·Menopause : the Journal of the North American Menopause Society·Claudia MarchettiPerluigi Bendetti Panici
Aug 17, 2020·The Journal of Clinical Endocrinology and Metabolism·Carolyn J CrandallJanet Sinsheimer

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