Gynecological efficacy and chemical investigation of Vitex agnus-castus L. fruits growing in Egypt

Natural Product Research
N A IbrahimE M Hassan

Abstract

Flavonoid glycosides, orientin and apigenin 3, 8-di-C-glycosides in addition to, iridoid compound, aucubin were isolated from the ethanolic extract of Vitex agnus-castus fruits. Their structures were identified on the basis of the spectroscopic data. The estrogenic activity of the ethanolic extract in two dose levels 0.6 and 1.2 g kg(-1) per body weight (b.w.) was studied by the vaginal smear, and uterine weight methods for normal and ovariectomized female rats. The extract induced significant increase in the uterine weight of ovariectomized rats at two dose levels comparable to that of control group. The percentages of the total average number of scores were increased significantly too. Significant increases in plasma progesterone and total estrogens levels were shown at the two dose levels when compared to that of control group. On the other side, the extract induced significant reduction in luteinizing and plasma prolactin hormones.

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Citations

May 18, 2010·Journal of Natural Medicines·Rosi Zanoni Da SilvaValdir Cechinel-Filho
Feb 15, 2013·Planta medica·Atieh HajirahimkhanJudy L Bolton
Nov 20, 2013·The Journal of Obstetrics and Gynaecology Research·Ayse Nur AksoySuna Kabil Kucur
Sep 7, 2016·Journal of the Chinese Medical Association : JCMA·Akram AhangarpourYaghoob Farbood
Sep 30, 2016·Pharmacological Reviews·Birgit M DietzJudy L Bolton
Dec 17, 2014·Metabolic Brain Disease·K V Simonyan, V A Chavushyan

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Methods Mentioned

BETA
chemical shift

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