Abstract
Flavonoid glycosides, orientin and apigenin 3, 8-di-C-glycosides in addition to, iridoid compound, aucubin were isolated from the ethanolic extract of Vitex agnus-castus fruits. Their structures were identified on the basis of the spectroscopic data. The estrogenic activity of the ethanolic extract in two dose levels 0.6 and 1.2 g kg(-1) per body weight (b.w.) was studied by the vaginal smear, and uterine weight methods for normal and ovariectomized female rats. The extract induced significant increase in the uterine weight of ovariectomized rats at two dose levels comparable to that of control group. The percentages of the total average number of scores were increased significantly too. Significant increases in plasma progesterone and total estrogens levels were shown at the two dose levels when compared to that of control group. On the other side, the extract induced significant reduction in luteinizing and plasma prolactin hormones.
References
Sep 25, 1976·Lancet·U HalbreichR Bornstein
Apr 1, 1978·Endocrinology·Y NakaiE Knobil
Oct 1, 1975·The Journal of Endocrinology·P De MoorG Verhoeven
Jan 16, 1974·Life Sciences·S H Shin, J Kraicer
Oct 1, 1972·The Journal of Clinical Endocrinology and Metabolism·A E SchindlerE Friedrich
Feb 1, 1972·The Journal of Clinical Endocrinology and Metabolism·G E AbrahamK Hopper
Nov 1, 1969·Endocrinology·R M MacLeod
Jan 1, 1994·Experimental and Clinical Endocrinology·H JarryW Wuttke
Oct 23, 1997·Phytochemistry·C HirobeH Itokawa
May 14, 1998·Chemical & Pharmaceutical Bulletin·E OkuyamaT Deyama
Sep 19, 1998·Planta medica·K M YouH P Kim
Feb 26, 1999·Biochemical Pharmacology·S M HyderG M Stancel
Mar 11, 1999·Archives of Pharmacal Research·K M YouH P Kim
May 18, 1999·Journal of Women's Health·G A Colditz
Jan 5, 2001·Phytochemistry·M OnoT Nohara
Feb 14, 2002·Planta medica·A SuksamrarnS Suksamrarn
Apr 27, 2002·Journal of Natural Products·Masateru OnoToshihiro Nohara
Oct 2, 2002·Complementary Therapies in Nursing & Midwifery·Barbara Chopin LucksLowana Veal
Oct 19, 2002·The American Journal of the Medical Sciences·Lori RussellC Andrew Brown
Jun 18, 2003·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·W WuttkeD Seidlová-Wuttke
Aug 5, 2003·Phytochemistry·Ayşe Kuruüzüm-UzAxel Zeeck
Dec 4, 2003·Planta medica·Hubertus JarryVolker Christoffel
Feb 21, 2004·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·J LiuN R Farnsworth
Jan 30, 2007·Planta medica·S SuksamrarnA Suksamrarn
Citations
May 18, 2010·Journal of Natural Medicines·Rosi Zanoni Da SilvaValdir Cechinel-Filho
Feb 15, 2013·Planta medica·Atieh HajirahimkhanJudy L Bolton
Aug 21, 2010·The Journal of Sexual Medicine·Renata Mazaro-CostaSergio Tufik
Nov 20, 2013·The Journal of Obstetrics and Gynaecology Research·Ayse Nur AksoySuna Kabil Kucur
Dec 20, 2014·BMC Complementary and Alternative Medicine·Susan ArentzAlan Bensoussan
Sep 7, 2016·Journal of the Chinese Medical Association : JCMA·Akram AhangarpourYaghoob Farbood
Sep 30, 2016·Pharmacological Reviews·Birgit M DietzJudy L Bolton
Dec 17, 2014·Metabolic Brain Disease·K V Simonyan, V A Chavushyan