Gynecological malignancy risk in colorectal cancer survivors: A population-based cohort study

European Journal of Oncology Nursing : the Official Journal of European Oncology Nursing Society
Wei-Chun ChangChia-Hung Kao

Abstract

This study was carried out to assess the risk of gynecological malignancy in colorectal cancer survivors using a population-based retrospective cohort study. Using the National Health Insurance Research Database (NHIRD) of Taiwan, we identified 37,176 patients with colorectal cancer diagnosed in 1998-2009, aged 20 years and above, without other cancer history. We also randomly selected 148,700 women without any cancer in the comparison cohort, frequency matched by age and diagnosis date. Incidences and hazards of breast, cervix, endometrial and ovarian cancers were evaluated by 201l. The overall incidence of the 4 types of gynecological cancer was 39.0% higher in colorectal cancer patients than in comparisons (2.99 vs. 2.14 per 1000 person-years) with an adjusted hazard ratio (HR) of 1.46 (95% confidence interval (CI) = 1.31-1.62). Breast cancer accounted for most subsequent cancer. The multivariable Cox method measured HR was the highest for endometrial cancer (3.40, 95% CI = 2.59-4.47) for the colorectal cohort relative to comparisons, followed by ovarian cancer and breast cancer, except cervix cancer. The risk of gynecological malignancies was apparently elevated for colorectal cancer survivors <50 years of age. Follow-up me...Continue Reading

References

May 22, 2003·Health Affairs·Jui-Fen Rachel Lu, William C Hsiao
Jan 5, 2006·Journal of the National Cancer Institute·Lois B TravisMark H Greene
Apr 12, 2007·Journal of Clinical Gastroenterology·Radhika SrinivasanJames D Lewis
Apr 9, 2008·Hematology/oncology Clinics of North America·Andrea K Ng, Lois B Travis

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Citations

Aug 26, 2021·International Journal of Colorectal Disease·Richard van der MeerRudi Roumen

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